Affinity DataKi: 0.00200nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00300nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00700nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.00900nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0420nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0560nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.229nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.380nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.469nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research
Curated by ChEMBL
Searle Discovery Research
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 0.620nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research
Curated by ChEMBL
Searle Discovery Research
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Bacillus anthracis)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Un-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Bacillus anthracis)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research
Curated by ChEMBL
Searle Discovery Research
Curated by ChEMBL
Affinity DataKi: 3.20nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitroMore data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research
Curated by ChEMBL
Searle Discovery Research
Curated by ChEMBL
Affinity DataKi: 4.10nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined.More data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 4.40nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Un-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Un-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 5.20nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Non-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research
Curated by ChEMBL
Searle Discovery Research
Curated by ChEMBL
Affinity DataKi: 6.70nMAssay Description:Binding affinity of the compound for HIV-1 protease was determinedMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Bacillus anthracis)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Searle Discovery Research
Curated by ChEMBL
Searle Discovery Research
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Binding affinity of the compound for HIV-1 protease was determined in vitro.More data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Bacillus anthracis)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Non-competitive inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human PNP by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
TargetS-methyl-5'-thioadenosine phosphorylase(Homo sapiens (Human))
Industrial Research
Curated by ChEMBL
Industrial Research
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of human MTAP assessed as reduction in methylthioadenosine phosphorolysis/hydrolysisMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Un-competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before IMP substrate addition by spectrophotometryMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase(Cryptosporidium parvum)
Brandeis University
Curated by ChEMBL
Brandeis University
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Competitive inhibition of Cryptosporidium IMPDH preincubated for 10 mins before NAD+ substrate addition by spectrophotometryMore data for this Ligand-Target Pair