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PDB Reactome pathway KEGG
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Kynurenine 3-monooxygenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50266041(CHEMBL4070212)

Ki: 0.100nMAssay Description:Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...More data for this Ligand-Target Pair

PC cid PC sid Similars

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402454(CHEMBL2208337)

Ki: 0.320nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402442(CHEMBL2208303)

Ki: 0.800nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402459(CHEMBL2208301)

Ki: 0.900nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

CHEMBL PC cid PC sid

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Kynurenine 3-monooxygenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

BDBM50266064(CHEMBL4104310)

Ki: 1nMAssay Description:Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...More data for this Ligand-Target Pair

PC cid PC sid Similars

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16171(2-[4-chloro-7-({1-[(4-methylpiperazin-1-yl)carbony...)

Ki: 1.40nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16170(2-(4-chloro-7-{[1-(morpholin-4-ylcarbonyl)cyclopen...)

Ki: 1.60nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402449(CHEMBL2208325)

Ki: 2nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402453(CHEMBL2208338)

Ki: 2nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16165(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 2.60nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 2(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402444(CHEMBL2208319)

Ki: 4nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 2(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402453(CHEMBL2208338)

Ki: 4nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402452(CHEMBL2208320)

Ki: 5nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16154(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 5.80nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402451(CHEMBL2208322)

Ki: 6nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16156(4-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 7.40nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16153(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16155(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 8nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 2(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402451(CHEMBL2208322)

Ki: 9nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16159((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)

Ki: 9.90nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402444(CHEMBL2208319)

Ki: 10nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16152(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 10nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16169(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

KEGG PC cid PC sid Patents Similars

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402457(CHEMBL2208340)

Ki: 11nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16157(4-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 11nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16164(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16166(cycloleucine deriv. 40 | ethyl 1-({4-chloro-1-[(di...)

Ki: 14nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402443(CHEMBL2208299)

Ki: 15nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16129(1-isoquinolinylguanidine 3 | 3-{4-chloro-1-[(diami...)

Ki: 17nM ΔG°: -46.1kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16148((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)

Ki: 19nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16147((2S)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)

Ki: 21nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50336912(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)

Ki: 22nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

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Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 2(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402457(CHEMBL2208340)

Ki: 22nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16150((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)

Ki: 22nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402458(CHEMBL2208339)

Ki: 23nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16161((2R)-1-({4-chloro-1-[(diaminomethylidene)amino]iso...)

Ki: 23nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16151((2S)-2-[benzyl({4-chloro-1-[(diaminomethylidene)am...)

Ki: 27nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16146((2R)-2-({4-chloro-1-[(diaminomethylidene)amino]iso...)

Ki: 28nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16143(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 29nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402440(CHEMBL2208305)

Ki: 29nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16168(1-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 30nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16145(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)

Ki: 31nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16144(2-[benzyl({4-chloro-1-[(diaminomethylidene)amino]i...)

Ki: 35nMAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 1(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402446(CHEMBL2208316)

Ki: 35nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 2(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50336912(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)

Ki: 43nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16141(1-guanidino-7-sulfonamidoisoquinoline 15 | 3-({4-c...)

Ki: 43nM ΔG°: -43.7kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Kynurenine 3-monooxygenase(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL

BDBM50266003(CHEMBL4091152)

Ki: 45nMAssay Description:Inhibition of rat KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair

PC cid PC sid PDB

Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Neuropeptide FF receptor 2(Homo sapiens (Human))
University Of Strasbourg

Curated by ChEMBL

BDBM50402447(CHEMBL2208312)

Ki: 47nMAssay Description:Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Urokinase-type plasminogen activator(Homo sapiens (Human))
Pfizer

BDBM16139(1-guanidino-7-sulfonamidoisoquinoline 13 | 2-({4-c...)

Ki: 48nM ΔG°: -43.5kJ/molepH: 8.1 T: 2°CAssay Description:Ki values for compounds were calculated by incubation of each enzyme with its substrate and various compound concentrations. Absorbance was read at 4...More data for this Ligand-Target Pair