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Found 235 with Last Name = 'huet' and Initial = 's'
TargetPapain(Carica papaya)
University Of Applied Sciences Of Darmstadt

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of papaya papain using cbzFRamc substrate preincubated for 10 mins followed by addition of substrate and measured every 30 sec for 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Applied Sciences Of Darmstadt

Curated by ChEMBL
LigandPNGBDBM50553988(Antipain)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of papaya papain using cbzFRamc substrate preincubated for 10 mins followed by addition of substrate and measured every 30 sec for 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28691(5-methyl-2-({3-[(7-methyl-1H-indole-1-)sulfonyl]be...)
Affinity DataIC50:  4nM EC50:  79nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28674(2-({3-[(2-carboxy-4-chlorophenyl)carbamoyl]benzene...)
Affinity DataIC50:  4nM EC50:  1.26E+3nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28669(2-{[3-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)b...)
Affinity DataIC50:  5nM EC50:  158nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28670(4-bromo-2-{[3-(1,2,3,4-tetrahydroisoquinoline-2-su...)
Affinity DataIC50:  5nM EC50:  158nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataIC50:  5nM EC50:  3nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151362(4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28695(5-chloro-2-({3-[(4-methoxy-1H-indole-1-)sulfonyl]b...)
Affinity DataIC50:  6nM EC50:  158nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28682(5-methyl-2-({3-[(4-methyl-1H-indole-1-)sulfonyl]be...)
Affinity DataIC50:  6nM EC50:  20nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Applied Sciences Of Darmstadt

Curated by ChEMBL
LigandPNGBDBM50553989(CHEMBL4764505)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of papaya papain using cbzFRamc substrate preincubated for 10 mins followed by addition of substrate and measured every 30 sec for 60 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM28667(5-bromo-2-{[3-(1,2,3,4-tetrahydroisoquinoline-2-su...)
Affinity DataIC50:  8nM EC50:  200nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28666(5-chloro-2-{[3-(1,2,3,4-tetrahydroisoquinoline-2-s...)
Affinity DataIC50:  8nM EC50:  126nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28684(2-({3-[(4-methoxy-1H-indole-1-)sulfonyl]benzene}am...)
Affinity DataIC50:  10nM EC50:  40nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28685(5-methyl-2-({3-[(5-methyl-1H-indole-1-)sulfonyl]be...)
Affinity DataIC50:  10nM EC50:  32nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28688(5-methyl-2-({3-[(6-methyl-1H-indole-1-)sulfonyl]be...)
Affinity DataIC50:  10nM EC50:  50nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151353(4-(4-Fluoro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28683(2-({3-[(4-bromo-1H-indole-1-)sulfonyl]benzene}amid...)
Affinity DataIC50:  10nM EC50:  13nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28675(2-[(3-{[5-(carboxymethoxy)-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50:  10nM EC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151357(2-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyri...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151362(4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28676(5-chloro-2-({3-[(6-methoxy-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50:  10nM EC50:  794nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184871(4-{2-[(4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-pyr...)
Affinity DataIC50:  12nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28697(5-chloro-2-({3-[(6-methoxy-1H-indole-1-)sulfonyl]b...)
Affinity DataIC50:  13nM EC50:  100nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28696(5-chloro-2-({3-[(5-methoxy-1H-indole-1-)sulfonyl]b...)
Affinity DataIC50:  13nM EC50:  158nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28672(5-chloro-2-({3-[(5-methoxy-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50:  13nM EC50:  1.26E+3nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28665(5-methyl-2-{[3-(1,2,3,4-tetrahydroisoquinoline-2-s...)
Affinity DataIC50:  13nM EC50:  200nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184879(CHEMBL424676 | dimethyl-{2-[(4-{4-[3-(pyridin-2-yl...)
Affinity DataIC50:  15nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28692(2-({3-[(7-chloro-1H-indole-1-)sulfonyl]benzene}ami...)
Affinity DataIC50:  16nM EC50:  158nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28698(5-chloro-2-({3-[(5-methoxy-4-methyl-1H-indole-1-)s...)
Affinity DataIC50:  16nM EC50:  16nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293525(5-methyl-2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human ALK5 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28679(5-chloro-2-({3-[(7-chloro-8-methyl-1,2,3,4-tetrahy...)
Affinity DataIC50:  16nM EC50:  316nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28677(5-chloro-2-({3-[(7-fluoro-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  16nM EC50:  1.00E+3nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Applied Sciences Of Darmstadt

Curated by ChEMBL
LigandPNGBDBM50553990(CHEMBL4788595)
Affinity DataIC50:  18nMAssay Description:Inhibition of papaya papain using cbzFRamc substrate preincubated for 10 mins followed by addition of substrate and measured every 30 sec for 60 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184872(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Affinity DataIC50:  18nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184890(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]-2-[4-(1-pyrro...)
Affinity DataIC50:  19nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50184887(2-{4-[(2-chloroethyl)oxy]phenyl}-4-[3-(pyridin-2-y...)
Affinity DataIC50:  19nMAssay Description:Displacement of rhodamine green fluorescently labeled ATP from recombinant GST-ALK5 by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28673(5-chloro-2-({3-[(5-hydroxy-1,2,3,4-tetrahydroisoqu...)
Affinity DataIC50:  20nM EC50:  2.00E+3nMpH: 7.0 T: 2°CAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28686(2-({3-[(5-chloro-1H-indole-1-)sulfonyl]benzene}ami...)
Affinity DataIC50:  20nM EC50:  50nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28694(2-({3-[(5-methoxy-4-methyl-1H-indole-1-)sulfonyl]b...)
Affinity DataIC50:  20nM EC50:  13nMAssay Description:Competition-binding curves for test compounds were determined with expressed human PPAR LBD. Plots of inhibitor concentration versus cpm of radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151347(2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-n...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.020-0.026)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.020-0.026)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151346(5-(1,5-naphthyridin-2-yl)-4-(pyridin-2-yl)thiazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151362(4-(6-Methyl-pyridin-2-yl)-5-[1,5]naphthyridin-2-yl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.019-0.032)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293515(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human ALK5 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50293527(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinolin-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human ALK5 kinase expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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