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Found 320 with Last Name = 'hulme' and Initial = 'c'
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.25nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM86231(ATR | ATROPINE | Atropine,(-) | CAS_51-55-8 | CHEM...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM86231(ATR | ATROPINE | Atropine,(-) | CAS_51-55-8 | CHEM...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.630nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM86231(ATR | ATROPINE | Atropine,(-) | CAS_51-55-8 | CHEM...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50176065(4-DAMP | 4-Diphenylacetoxy-1,1-dimethyl-piperidini...)
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  2nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216147(CHEMBL134237)
Affinity DataKi:  4.30nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM81937(CAS_9050-30-0 | HS,(+/-) | Heparitin, sulfate)
Affinity DataKi:  6.31nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215950(CHEMBL55046)
Affinity DataKi:  7nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215392(CHEMBL131565)
Affinity DataKi:  7.5nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50071173((3R,4R,4aS,8aR)-4-[(E)-2-((2S,6S)-1,6-Dimethyl-pip...)
Affinity DataKi:  7.94nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50176065(4-DAMP | 4-Diphenylacetoxy-1,1-dimethyl-piperidini...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214362(CHEMBL102635)
Affinity DataKi:  12nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute For Medical Research

Curated by PDSP Ki Database
LigandPNGBDBM81937(CAS_9050-30-0 | HS,(+/-) | Heparitin, sulfate)
Affinity DataKi:  12.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  13nMAssay Description:Activity at rat MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215947(CHEMBL53710)
Affinity DataKi:  13nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50079881(3-(7-Carbamimidoyl-naphthalen-2-yl)-2-{4-[1-(1-imi...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  13nMAssay Description:Activity at human MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  14nMAssay Description:Activity at mouse MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50079882(1-[(R)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215945(CHEMBL54988)
Affinity DataKi:  21nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50070632(4-[2-(3-Benzenesulfonylamino-phenoxy)-ethylamino]-...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215955(CHEMBL301448)
Affinity DataKi:  24nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214422(CHEMBL101479)
Affinity DataKi:  30nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215125(CHEMBL102503)
Affinity DataKi:  30nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215127(CHEMBL102310)
Affinity DataKi:  38nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215948(CHEMBL54361)
Affinity DataKi:  41nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216148(CHEMBL335380)
Affinity DataKi:  43nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215391(CHEMBL334765)
Affinity DataKi:  51nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214506(CHEMBL323069)
Affinity DataKi:  51nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215953(CHEMBL292925)
Affinity DataKi:  54nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214749(CHEMBL102741)
Affinity DataKi:  60nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215944(CHEMBL54590)
Affinity DataKi:  60nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215057(CHEMBL322837)
Affinity DataKi:  64nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215952(CHEMBL55203)
Affinity DataKi:  66nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215126(CHEMBL414417)
Affinity DataKi:  67nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214380(CHEMBL323132)
Affinity DataKi:  67nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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