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Found 192 with Last Name = 'ibrar' and Initial = 'a'
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 10 mins by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276359(CHEMBL4129303)
Affinity DataIC50:  0.134nMAssay Description:Inhibition of human MAO-B using p-tyramine as substrate after 15 mins by amplex red reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Quaid-I-Azam University

LigandPNGBDBM218829(1,4-Bis(2-pentanoylimino-5-(2-methoxy-2-oxoethylid...)
Affinity DataIC50:  1nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50044260(CHEMBL3310053)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Quaid-I-Azam University

LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  4.5nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276368(CHEMBL4128371)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Quaid-I-Azam University

LigandPNGBDBM218826(1,2-Bis(2-(2-chlorobenzoylimino)-5-(2-methoxy-2-ox...)
Affinity DataIC50:  9nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50044259(CHEMBL3310052)
Affinity DataIC50:  12nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM39862(Deprenyl | METHYL-(1-METHYL-2-PHENYL-ETHYL)-PROP-2...)
Affinity DataIC50:  19.6nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM15579(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human MAO-B using p-tyramine as substrate after 15 mins by amplex red reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50044261(CHEMBL3310054)
Affinity DataIC50:  27nMAssay Description:Inhibition of c-Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  30nMAssay Description:Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50433370(CHEMBL2375482)
Affinity DataIC50:  61nMAssay Description:Inhibition of calf intestinal alkaline phosphatase using p-NPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  86nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50448067(CHEMBL3115730)
Affinity DataIC50:  100nMAssay Description:Inhibition of DHFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193852((E)-3-(2-(2-(1-(4-bromophenyl)ethylidene)hydraziny...)
Affinity DataIC50:  110nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Bos taurus)
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM193852((E)-3-(2-(2-(1-(4-bromophenyl)ethylidene)hydraziny...)
Affinity DataIC50:  110nMAssay Description:Inhibition of calf lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193848(Coumarin-thiazole series I, 6a)
Affinity DataIC50:  120nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193850((E)-3-(2-(2-(1-(2-bromophenyl)ethylidene)hydraziny...)
Affinity DataIC50:  160nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM218824(1,2-Bis(2-octanoylimino-5-(2-methoxy-2-oxoethylide...)
Affinity DataIC50:  200nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM218823(1,2-Bis(2-pentanoylimino-5-(2-methoxy-2-oxoethylid...)
Affinity DataIC50:  210nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataIC50:  293nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Bos taurus)
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM193866(3-(4-((2-Chlorophenylamino)methyl)-5-thioxo-4,5-di...)
Affinity DataIC50:  310nMAssay Description:Inhibition of calf lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276310(CHEMBL4127794)
Affinity DataIC50:  310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193866(3-(4-((2-Chlorophenylamino)methyl)-5-thioxo-4,5-di...)
Affinity DataIC50:  310nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276360(CHEMBL4126559)
Affinity DataIC50:  310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276366(CHEMBL4129984)
Affinity DataIC50:  310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276369(CHEMBL4127948)
Affinity DataIC50:  310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM218822(1,2-Bis(2-butanoylimino-5-(2-methoxy-2-oxoethylide...)
Affinity DataIC50:  330nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Bos taurus)
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM193869(3-(4-(Morpholinomethyl)-5-thioxo-4,5-dihydro-1,3,4...)
Affinity DataIC50:  340nMAssay Description:Inhibition of calf lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  340nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193869(3-(4-(Morpholinomethyl)-5-thioxo-4,5-dihydro-1,3,4...)
Affinity DataIC50:  340nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50276367(CHEMBL4129191)
Affinity DataIC50:  390nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193860((E)-3-(2-(2-((2-amino-4-chlorophenyl)(phenyl)methy...)
Affinity DataIC50:  459nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Bos taurus)
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM193860((E)-3-(2-(2-((2-amino-4-chlorophenyl)(phenyl)methy...)
Affinity DataIC50:  459nMAssay Description:Inhibition of bovine kidney ALR1 using D-glucoronic acid as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50448066(CHEMBL3115731)
Affinity DataIC50:  500nMAssay Description:Inhibition of DHFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Abbottabad University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM218829(1,4-Bis(2-pentanoylimino-5-(2-methoxy-2-oxoethylid...)
Affinity DataIC50:  510nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50028572(CHEMBL3338952)
Affinity DataIC50:  585nMAssay Description:Inhibition of human BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Quaid-I-Azam University

LigandPNGBDBM218831(1,4-Bis(2-benzoylimino-5-(2-methoxy-2-oxoethyliden...)
Affinity DataIC50:  740nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50004319(CHEMBL3237541)
Affinity DataIC50:  770nMAssay Description:Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50028612(CHEMBL1466313)
Affinity DataIC50:  781nMAssay Description:Inhibition of human BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50004306(CHEMBL3237531)
Affinity DataIC50:  920nMAssay Description:Inhibition of calf intestinal alkaline phosphatase using p-nitrophenyl phosphate as substrate preincubated for 10 mins before substrate addition afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Quaid-I-Azam University

LigandPNGBDBM218824(1,2-Bis(2-octanoylimino-5-(2-methoxy-2-oxoethylide...)
Affinity DataIC50:  930nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50062329(CHEMBL3397276)
Affinity DataIC50:  950nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Quaid-I-Azam University

LigandPNGBDBM218823(1,2-Bis(2-pentanoylimino-5-(2-methoxy-2-oxoethylid...)
Affinity DataIC50:  990nMpH: 7.4Assay Description:The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member A1(Bos taurus (Cattle))
Comsats Institute of Information Technology

LigandPNGBDBM193856((E)-3-(2-(2-(1-(3-fluoro-4-methoxyphenyl)ethyliden...)
Affinity DataIC50:  1.08E+3nMpH: 6.2Assay Description:The assay results were obtained at 340 nm and ALR1 inhibitory activity was measured with the absorbance change at this respective wavelength. Each we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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