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TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094650(CHEMBL434060 | N-(4-Amino-2-ethyl-quinolin-6-yl)-2...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094648(CHEMBL139776 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094640(CHEMBL140640 | N-(4-Amino-2-propyl-quinolin-6-yl)-...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094651(CHEMBL342580 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  2.20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094638(CHEMBL337128 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  2.30nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094642(CHEMBL142454 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  2.60nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094646(CHEMBL139934 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  6.5nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094636(CHEMBL140103 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  7nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  8.20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094644(CHEMBL140519 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094639(CHEMBL142999 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  13nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094647(CHEMBL143605 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094649(CHEMBL140580 | N-(1-Amino-3-methyl-isoquinolin-7-y...)
Affinity DataKi:  37nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094637(CHEMBL139566 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  47nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094635(CHEMBL336238 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  51nMAssay Description:Compound was evaluated for its ability to displace [3H]-nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataKi:  68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094643(CHEMBL358306 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  80nMAssay Description:Compound was evaluated for its ability to displace [3H]-nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094641(CHEMBL422641 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  82nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094645(CHEMBL143243 | N-(4-Amino-quinolin-6-yl)-2-(4-chlo...)
Affinity DataKi:  86nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094652(CHEMBL343424 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  89nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  103nMAssay Description:Inhibition of [3H]diprenorphine (0.33 nM) binding from human Opioid receptor mu 1 expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094653(CHEMBL141078 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  121nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094654(Biphenyl-2-carboxylic acid (4-amino-2-methyl-quino...)
Affinity DataKi:  369nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataKi:  470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibition of [3H]naltrindole (0.55 nM) binding from human Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  8.65E+3nMAssay Description:Inhibition of [3H]naltrindole (0.55 nM) binding from human Opioid receptor delta 1 expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671244((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.300nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671279((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-b...)
Affinity DataIC50:  0.300nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672675((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.330nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671846((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.330nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672599((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.330nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671102((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.330nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671343((5S,8S,11S,15S,18S,23aS,29S,35S,37aS)-8-((S)-sec-b...)
Affinity DataIC50:  0.350nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671722((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclo...)
Affinity DataIC50:  0.350nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671446((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclo...)
Affinity DataIC50:  0.350nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672081((3S,9S,18S,21S,25S,28S,34S,36R)-3-[2-[3-chloro-4-(...)
Affinity DataIC50:  0.360nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671243((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.370nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672486((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.370nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671849((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.370nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672608((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.380nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672410((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.380nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM671322((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.380nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672016((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclo...)
Affinity DataIC50:  0.390nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672532((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.400nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672447((6S,9S,13S,16S,22S,25S,31S,34S)-25-[2-[3-chloro-4-...)
Affinity DataIC50:  0.410nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672485((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.410nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672584((3S,9S,18S,21S,25S,28S,34S)-3-[2-[3-chloro-4-(trif...)
Affinity DataIC50:  0.410nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672774((3S,9S,18S,21S,25S,28S,34S,36S)-3-[2-[3-chloro-4-(...)
Affinity DataIC50:  0.410nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Chugai Seiyaku Kabushiki Kaisha

US Patent
LigandPNGBDBM672093((3S,9S,18S,21S,25S,28S,34S)-28-cyclohexyl-9-(cyclo...)
Affinity DataIC50:  0.420nMAssay Description:Protein-protein interaction inhibition (PPI) between Kras and SOS1 was measured by energy transfer from nickel-conjugated donor beads to streptavidin...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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