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Found 362 with Last Name = 'iqbal' and Initial = 'm'
TargetChymotrypsin-C(Homo sapiens (Human))
University of Karachi

LigandPNGBDBM87059(CHEMBL247767 | Chymostatin)
Affinity DataKi:  8.24E+3nM ΔG°:  -29.0kJ/molepH: 7.6 T: 2°CAssay Description:Chymotrypsin inhibitory activity of compunds was perfomred by the method of Cannel.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
University of Karachi

LigandPNGBDBM87058(Lignan, 3 | MLS000034632 | N-tert-Butyl-N-(tert-bu...)
Affinity DataKi:  3.18E+4nM ΔG°:  -25.7kJ/molepH: 7.6 T: 2°CAssay Description:Chymotrypsin inhibitory activity of compunds was perfomred by the method of Cannel.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
University of Karachi

LigandPNGBDBM87060(Lignan, 4 | MLS001138823 | N-(4-methylcyclohexyl)-...)
Affinity DataKi:  4.71E+4nM ΔG°:  -24.7kJ/molepH: 7.6 T: 2°CAssay Description:Chymotrypsin inhibitory activity of compunds was perfomred by the method of Cannel.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant LckMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Tyrosine-protein kinase receptor FLT3 (fms-related tyrosine kinase 3) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  2nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611818(CHEMBL5275393)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50031442(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50611818(CHEMBL5275393)
Affinity DataIC50:  3nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136019(9-ethoxymethyl-12-(3-hydroxypropyl)-6,7,12,13-tetr...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291219(CHEMBL151521 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291234(CHEMBL150600 | [(S)-1-((S)-1-Formyl-2-methyl-propy...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Government College University

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291225(CHEMBL357595 | {(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50084655(CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  6nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182149(4-((4-bromo-1-methyl-1H-indol-3-yl)methylene)-3-(p...)
Affinity DataIC50:  6nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291188(((S)-1-{(R)-1-[(S)-1-((S)-1-Formyl-3-methyl-butylc...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50031440(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Affinity DataIC50:  6nMAssay Description:Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291222(CHEMBL423222 | {(S)-1-[(S)-1-(4-Benzyloxy-benzyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136008(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-like protease CTRL-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288611(Alpha-ketocarbonyl boronic ester derivative | CHEM...)
Affinity DataIC50:  8nMAssay Description:Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291192(CHEMBL345337 | [(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291228(CHEMBL347742 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291236(CHEMBL356841 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50218973(CHEMBL44001)
Affinity DataIC50:  8.32nMAssay Description:Inhibition of mouse COX-2 in LPS-induced mouse peritoneal macrophage assessed as reduction in PGE2 release incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182139(4-((4-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50:  9nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291223(CHEMBL150134 | Naphthalene-2-carboxylic acid {(S)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50182144(4-((5-chloro-1-methyl-1H-indol-3-yl)methylene)-3-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2(Apis mellifera)
Jamia Hamdard

Curated by ChEMBL
LigandPNGBDBM50524139(CHEMBL4467602)
Affinity DataIC50:  10nMAssay Description:Inhibition of bee venom phospholipase A2 preincubated for 1 hr followed by addition of phosphotidylcholine and 1-palmitoyl-2-(1-14C) palmitoyl furthe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50137397(CHEMBL341014 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291194((S)-2-Methanesulfonylamino-4-methyl-pentanoic acid...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291218(CHEMBL2371036 | [(S)-1-(1-Formyl-propylcarbamoyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291226(CHEMBL151829 | [(S)-1-((S)-1-Cyclohexylmethyl-2-ox...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136018(9-(tert-butoxymethyl)-12-(3-hydroxypropyl)-6,7,12,...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50142287((S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity of the compound was evaluated against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291197(CHEMBL149754 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291187(CHEMBL151370 | {(S)-1-[(R)-1-((R)-1-Formyl-3-methy...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50024274(CHEMBL2448133)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory concentration against human vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136013(9-(sec-butoxymethyl)-12-(3-hydroxypropyl)-6,7,12,1...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291205(CHEMBL358404 | [(S)-1-((S)-1-Formyl-3-methyl-butyl...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291177((S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-(...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291181(CHEMBL150976 | {(S)-2-tert-Butoxy-1-[(R)-1-((R)-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM193425(US9199944, 7)
Affinity DataIC50:  12nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50136021(12-(3-hydroxypropyl)-9-propoxymethyl-6,7,12,13-tet...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291224(CHEMBL424142 | {(S)-1-[(S)-1-Formyl-2-(3H-imidazol...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291207(3-[(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoyl)-3-...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291176((S)-2-Acetylamino-4-methyl-pentanoic acid [(R)-1-(...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity evaluated against recombinant human calpain 1More data for this Ligand-Target Pair
In DepthDetails Article
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