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Found 86 with Last Name = 'karle' and Initial = 'm'
TargetSerine protease 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50092660(4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL1...)
Affinity DataKi:  8.90E+3nMAssay Description:Inhibition of human recombinant trypsin 1 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50092660(4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL1...)
Affinity DataKi:  1.31E+4nMAssay Description:Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50092660(4-Amino-benzamidine | 4-aminobenzamidine | CHEMBL1...)
Affinity DataKi:  9.50E+4nMAssay Description:Inhibition of human thrombin using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387180(CHEMBL2047998)
Affinity DataKi:  1.68E+5nMAssay Description:Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387180(CHEMBL2047998)
Affinity DataKi:  1.98E+5nMAssay Description:Inhibition of human recombinant trypsin 1 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387183(CHEMBL2048000)
Affinity DataKi:  4.76E+5nMAssay Description:Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387180(CHEMBL2047998)
Affinity DataKi:  4.81E+5nMAssay Description:Inhibition of human thrombin using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387183(CHEMBL2048000)
Affinity DataKi:  6.47E+5nMAssay Description:Inhibition of human recombinant trypsin 1 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387182(CHEMBL2048003)
Affinity DataKi:  7.94E+5nMAssay Description:Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387181(CHEMBL2047999)
Affinity DataKi:  1.09E+6nMAssay Description:Inhibition of human recombinant trypsin 4 using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50387181(CHEMBL2047999)
Affinity DataKi:  2.73E+6nMAssay Description:Inhibition of human thrombin using tosyl-GPR-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020035(CHEMBL3287849)
Affinity DataIC50:  280nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020042(CHEMBL3287856)
Affinity DataIC50:  360nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020037(CHEMBL3287854)
Affinity DataIC50:  390nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020036(CHEMBL3287851)
Affinity DataIC50:  440nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020036(CHEMBL3287851)
Affinity DataIC50:  440nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020043(CHEMBL3287857)
Affinity DataIC50:  450nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020033(CHEMBL3287847)
Affinity DataIC50:  580nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020039(CHEMBL3287852)
Affinity DataIC50:  770nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032954(5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...)
Affinity DataIC50:  800nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020035(CHEMBL3287849)
Affinity DataIC50:  950nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020038(CHEMBL3287850)
Affinity DataIC50:  1.02E+3nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020040(CHEMBL3287853)
Affinity DataIC50:  1.06E+3nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020041(CHEMBL3287855)
Affinity DataIC50:  1.26E+3nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50201426(dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-c...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020029(CHEMBL144416)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020031(CHEMBL3287844)
Affinity DataIC50:  2.10E+3nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50201425(2-({dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032954(5-(piperidin-4-yl)isoxazol-3-ol | 5-Piperidin-4-yl...)
Affinity DataIC50:  2.80E+3nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020033(CHEMBL3287847)
Affinity DataIC50:  2.90E+3nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Affinity DataIC50:  3.10E+3nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020029(CHEMBL144416)
Affinity DataIC50:  5.70E+3nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020031(CHEMBL3287844)
Affinity DataIC50:  6.30E+3nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Cyklokapron | Lysteda | TRANEXAMIC ACID...)
Affinity DataIC50:  1.20E+4nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032956(3-Piperidin-4-yl-isoxazol-5-ol | CHEMBL110210)
Affinity DataIC50:  1.22E+4nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408762(DESETHYLCHLOROQUINE | Desethyl chloroquine)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408763(CHEMBL343728)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM23300(4-amino-7-chloroquinoline (ACQ)-based compound, 5 ...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408770(CHEMBL143042 | TCMDC-124246)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408760(CHEMBL139984)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408771(CHEMBL344599)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408766(CHEMBL342499)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020028(CHEMBL3287843)
Affinity DataIC50:  3.10E+4nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50357211(177 J.D. | AMINOCAPROIC ACID | Amicar | Aminocapro...)
Affinity DataIC50:  4.00E+4nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020028(CHEMBL3287843)
Affinity DataIC50:  4.00E+4nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408768(CHEMBL423184)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408764(CHEMBL143439)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50408761(CHEMBL143522)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020027(CHEMBL3287842)
Affinity DataIC50:  1.00E+5nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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