Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50387183
Substrate
n/a
Meas. Tech.
ChEMBL_827952 (CHEMBL2051531)
Ki
647000±n/a nM
Citation
 Karle, M; Knecht, W; Xue, Y Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV. Bioorg Med Chem Lett 22:4839-43 (2012) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50387183
Synonyms:
CHEMBL2048000
Type:
Small organic molecule
Emp. Form.:
C8H7ClN4OS
Mol. Mass.:
242.685
SMILES:
[#7]\[#6](-[#7])=[#7]\c1nc2cc(Cl)c(-[#8])cc2s1
Structure:
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