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Found 367 with Last Name = 'labrie' and Initial = 'f'
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0150nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0160nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0230nMAssay Description:Stimulation of alkaline phosphatase activity in human endometrial Ishikawa cells with 1 nM E2 estradiolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471256(CHEMBL291808)
Affinity DataKi:  0.0280nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0420nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0470nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0690nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0760nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0900nMAssay Description:Apparent binding affinity against estradiol-stimulated ZR-75-1-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.113nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.120nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataKi:  0.126nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataKi:  0.128nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.138nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.181nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataKi:  0.249nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataKi:  0.346nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471258(CHEMBL67783)
Affinity DataKi:  0.525nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataKi:  0.668nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataKi:  0.755nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataKi:  1.5nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataKi:  1.80nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471257(CHEMBL67837)
Affinity DataKi:  1.90nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471257(CHEMBL67837)
Affinity DataKi:  2.10nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataKi:  2.30nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471253(CHEMBL441622)
Affinity DataKi:  4.20nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataKi:  4.60nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  4.70nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
Chul

LigandPNGBDBM17285((2R,15'S)-5,5,15'-trimethyl-6-oxospiro[oxane-2,14'...)
Affinity DataKi:  6.90nM ΔG°:  -48.5kJ/molepH: 7.5 T: 2°CAssay Description:A radioactive assay was used for the enzyme kinetics in the presence of EM1404 at different concentrations for its Ki determination. Reactions were i...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  11nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKi:  12nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKi:  34nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471253(CHEMBL441622)
Affinity DataKi: >270nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of estradiol-stimulated T-47D cell proliferation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of estradiol-stimulated T-47D cell proliferation.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
Laval University

Curated by ChEMBL
LigandPNGBDBM50369432(CHEMBL1627465)
Affinity DataIC50:  0.150nMAssay Description:Compound was tested for its ability to inhibit human embryonal kidney cell derived steroid sulfatase activity in transforming [3H]E1S (estrone sulfat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471256(CHEMBL291808)
Affinity DataIC50:  0.243nMAssay Description:Inhibition of estradiol-stimulated T-47D cell proliferation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
Laval University

Curated by ChEMBL
LigandPNGBDBM50369431(CHEMBL1627878)
Affinity DataIC50:  0.390nMAssay Description:Compound was tested for its ability to inhibit human embryonal kidney cell derived steroid sulfatase activity in transforming [3H]E1S (estrone sulfat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of estradiol-stimulated ZR-75-1-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034137(CHEMBL275153 | N-Pentyl-N-((4aR,6aS,7S,11aR)-1,4a,...)
Affinity DataIC50:  0.910nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataIC50:  1.30nMAssay Description:Stimulation of alkaline phosphatase activity in human endometrial Ishikawa cells with 1 nM E2 estradiolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
Laval University

Curated by ChEMBL
LigandPNGBDBM50369432(CHEMBL1627465)
Affinity DataIC50:  1.40nMAssay Description:Compound was tested for its ability to inhibit the transformation of [C14]-DHEAS to DHEA by steroid sulfatase derived from human embryonal kidney cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
Laval University

Curated by ChEMBL
LigandPNGBDBM50369740(CHEMBL1627637)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of steroid sulfatase activity by the compound was determined in human embryonic kidney (HEK)-293 cells transfected with a sulfatase expres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034151(CHEMBL280015 | Pentanoic acid pentyl-((4aR,6aS,7S,...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
Laval University

Curated by ChEMBL
LigandPNGBDBM50134329(CHEMBL122708 | Sulfamic acid (11R,12S,15S,16S)-13-...)
Affinity DataIC50:  2.10nMAssay Description:Compound was tested for its ability to inhibit human embryonal kidney cell derived steroid sulfatase activity in transforming [3H]E1S (estrone sulfat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034161(CHEMBL17245 | N-(4-Methoxy-phenyl)-N-((4aR,6aS,7S,...)
Affinity DataIC50:  2.10nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034134(CHEMBL17222 | N-(3-Methyl-butyl)-N-((4aR,6aS,7S,11...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034142(CHEMBL16863 | N-(3,3-Dimethyl-butyl)-N-((4aR,6aS,7...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Chul Research Center

Curated by ChEMBL
LigandPNGBDBM50034135(5-Bromo-pentanoic acid pentyl-((4aR,6aS,7S,11aR)-1...)
Affinity DataIC50:  2.40nMAssay Description:In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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