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Found 254 with Last Name = 'lahue' and Initial = 'b'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020149(CHEMBL3288449)
Affinity DataIC50:  24nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020151(CHEMBL3288451)
Affinity DataIC50:  24nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020150(CHEMBL3288450)
Affinity DataIC50:  24nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020150(CHEMBL3288450)
Affinity DataIC50:  24nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001929(CHEMBL3233018)
Affinity DataIC50:  40nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001929(CHEMBL3233018)
Affinity DataIC50:  41nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165695(CHEMBL3797513)
Affinity DataIC50:  42nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165701(CHEMBL3798136)
Affinity DataIC50:  111nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165697(CHEMBL3799374)
Affinity DataIC50:  114nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165700(CHEMBL3800127)
Affinity DataIC50:  144nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165721(CHEMBL3799375)
Affinity DataIC50:  150nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001920(CHEMBL3233588)
Affinity DataIC50:  169nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165705(CHEMBL3799552)
Affinity DataIC50:  173nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596680(CHEMBL5203689)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165719(CHEMBL3797331)
Affinity DataIC50:  224nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165720(CHEMBL3798260)
Affinity DataIC50:  267nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165707(CHEMBL3798271)
Affinity DataIC50:  293nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596688(CHEMBL5191746)
Affinity DataIC50:  300nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50001929(CHEMBL3233018)
Affinity DataIC50: <300nMAssay Description:Inhibition of CYP3A4 (unknown origin) pre-incubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001920(CHEMBL3233588)
Affinity DataIC50:  300nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596677(CHEMBL3805963)
Affinity DataIC50:  300nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50001920(CHEMBL3233588)
Affinity DataIC50:  300nMAssay Description:Inhibition of CYP3A4 (unknown origin) pre-incubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165718(CHEMBL3798706)
Affinity DataIC50:  334nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165716(CHEMBL3797521)
Affinity DataIC50:  376nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165696(CHEMBL3799031)
Affinity DataIC50:  392nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165723(CHEMBL3798014)
Affinity DataIC50:  399nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596682(CHEMBL5191489)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165708(CHEMBL3798889)
Affinity DataIC50:  492nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethy...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human kinesin spindle protein by endpoint assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165715(CHEMBL3800178)
Affinity DataIC50:  525nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596681(CHEMBL5181526)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001919(CHEMBL3233587)
Affinity DataIC50:  600nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165728(CHEMBL3798182)
Affinity DataIC50:  668nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165709(CHEMBL3799050)
Affinity DataIC50:  686nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165704(CHEMBL3798867)
Affinity DataIC50:  801nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50020151(CHEMBL3288451)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP3A4 (unknown origin) pre-incubated with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50169695(CHEMBL3805372)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001924(CHEMBL3233591)
Affinity DataIC50:  1.00E+3nMAssay Description:Binding affinity to HDM2 (unknown origin) by fluorescence polarization peptide displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165717(CHEMBL3799390)
Affinity DataIC50:  1.07E+3nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165713(CHEMBL3797577)
Affinity DataIC50:  1.15E+3nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596679(CHEMBL5191434)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293755(2-(3-fluoro-4-methoxyphenylamino)-1-(2-(trifluorom...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human kinesin spindle protein by endpoint assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293761(2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethy...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human kinesin spindle protein by endpoint assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596685(CHEMBL5183518)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165710(CHEMBL3799367)
Affinity DataIC50:  1.86E+3nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596683(CHEMBL5179234)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165722(CHEMBL3798021)
Affinity DataIC50:  1.92E+3nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165845(CHEMBL3797879)
Affinity DataIC50:  1.98E+3nMAssay Description:Binding affinity to human MDM2 assessed as inhibition of interaction with p53 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50596686(CHEMBL5189775)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrate pretreated with NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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