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Found 122 with Last Name = 'lee' and Initial = 'jd'
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50290908(CHEMBL4160428)
Affinity DataKi:  3.50E+3nMAssay Description:Competitive inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  8nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  24nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81552(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1...)
Affinity DataIC50:  41nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81550(Furan thiazolidinediones, A47)
Affinity DataIC50:  49nM Kd:  23nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81550(Furan thiazolidinediones, A47)
Affinity DataIC50:  49nM Kd:  40nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHomeodomain-interacting protein kinase 2(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM81551(Furan thiazolidinediones, A64)
Affinity DataIC50:  74nM Kd:  9.5nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against cdc25B phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337137(2-((2-methoxy-4-(4-(pyrrolidin-1-yl)piperidine-1-c...)
Affinity DataIC50:  130nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM36486(9-Cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-...)
Affinity DataIC50:  145nM Kd:  26nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against CD45 phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337127(2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino...)
Affinity DataIC50:  190nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337131(2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperid...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337139(11-ethyl-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337141(11-cyclopentyl-2-((2-methoxy-4-(4-methylpiperazin-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  220nMAssay Description:Inhibitory activity against Protein phosphatase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337130(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)-5,11...)
Affinity DataIC50:  230nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337140(11-isopropyl-2-((2-methoxy-4-(4-methylpiperazin-1-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337128(2-((4-(4-hydroxypiperidin-1-yl)-2-methoxyphenyl)am...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337134(2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)ami...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337138(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  240nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337129(2-((2-methoxy-4-morpholinophenyl)amino)-5,11-dimet...)
Affinity DataIC50:  260nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337132(2-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)ami...)
Affinity DataIC50:  260nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177324(2-(4-(7-pentadecanoylcyclopenta[d][1,2]oxazin-4-yl...)
Affinity DataIC50:  270nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337133(5,11-dimethyl-2-((2-methyl-4-(4-methylpiperazin-1-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337135(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  310nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337136(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  320nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  550nMAssay Description:Inhibitory activity against YOP protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against LAR protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177317(2-(4-(7-(4-methoxybenzoyl)cyclopenta[d][1,2]oxazin...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177316(2-(4-(7-(4-(aminomethyl)benzoyl)cyclopenta[d][1,2]...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibitory activity against YOP protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50290904(CHEMBL4168689)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177316(2-(4-(7-(4-(aminomethyl)benzoyl)cyclopenta[d][1,2]...)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibitory activity against CD45 phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337144(8-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177316(2-(4-(7-(4-(aminomethyl)benzoyl)cyclopenta[d][1,2]...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity against Protein phosphatase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337143(9-fluoro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)p...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibitory activity against cdc25A phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177322(2-(2,6-dibromo-4-(7-(4-methoxybenzoyl)cyclopenta[d...)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177320(2-(4-(7-(3-methoxybenzoyl)cyclopenta[d][1,2]oxazin...)
Affinity DataIC50:  1.96E+3nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177316(2-(4-(7-(4-(aminomethyl)benzoyl)cyclopenta[d][1,2]...)
Affinity DataIC50:  2.16E+3nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177318(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibitory activity against cdc25C phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50290907(CHEMBL4175528)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50337142(2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)ami...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177319((2,4-dichlorophenyl)(4-(4-methoxyphenyl)cyclopenta...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50290905(CHEMBL4173174)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase A(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50290903(CHEMBL4176543)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human recombinant alpha-galactosidase A using 4-MU-alpha-d-galactopyranoside as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177326(1-(4-benzylpiperazin-1-yl)-2-(4-(7-(4-methoxybenzo...)
Affinity DataIC50:  5.48E+3nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177325(2-(4-(7-(2-(4-methoxyphenyl)acetyl)cyclopenta[d][1...)
Affinity DataIC50:  5.63E+3nMAssay Description:Inhibitory activity against recombinant human PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase YopH(Yersinia enterocolitica)
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50177317(2-(4-(7-(4-methoxybenzoyl)cyclopenta[d][1,2]oxazin...)
Affinity DataIC50:  5.71E+3nMAssay Description:Inhibitory activity against YOP protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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