Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human PARP2 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human PARP1 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) by fluorescence based activity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human TNKS-1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of TNKS1 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS1 expressed in Sf9 cells incubated for 1 hr by histone ribosylation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS2 expressed in Sf9 cells incubated for 1 hr by histone ribosylation assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant TNKS1 by chemiluminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) by fluorescence based activity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous as...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant TNKS2 by chemiluminescent assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 151nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 181nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human TNKS-2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 283nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 316nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 685nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 707nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Perugia
Curated by ChEMBL
University Of Perugia
Curated by ChEMBL
Affinity DataIC50: 832nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 3.35E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma
Curated by ChEMBL
Tes Pharma
Curated by ChEMBL
Affinity DataIC50: 4.45E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PARP-1More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant rat CYP3A1 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous ass...More data for this Ligand-Target Pair