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Found 55 with Last Name = 'liscio' and Initial = 'p'
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human PARP2 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human PARP1 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50247642(CHEMBL4072240)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  4nMAssay Description:Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468271(CHEMBL4290134)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) by fluorescence based activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  11nMAssay Description:Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human TNKS-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)
Affinity DataIC50:  13nMAssay Description:Inhibition of TNKS1 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497560(CHEMBL3344071)
Affinity DataIC50:  19nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50126147(CHEMBL3629571)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261521(US10513499, Compound 4 | US11254644, Compound 4 | ...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497559(CHEMBL3344072)
Affinity DataIC50:  21nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497559(CHEMBL3344072)
Affinity DataIC50:  29nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468269(CHEMBL4285233)
Affinity DataIC50:  31nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS1 expressed in Sf9 cells incubated for 1 hr by histone ribosylation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468269(CHEMBL4285233)
Affinity DataIC50:  36nMAssay Description:Inhibition of N-terminal GST-tagged human TNKS2 expressed in Sf9 cells incubated for 1 hr by histone ribosylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261511(US10513499, Compound 1 | US11254644, Compound 1 | ...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant TNKS1 by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468272(CHEMBL4293376)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50188599(CHEMBL127066)
Affinity DataIC50:  59nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) by fluorescence based activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497560(CHEMBL3344071)
Affinity DataIC50:  80nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261535(US10513499, Compound 6 | US11254644, Compound 6 | ...)
Affinity DataIC50:  89nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468270(CHEMBL3344061)
Affinity DataIC50:  90nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468270(CHEMBL3344061)
Affinity DataIC50:  90nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261588(US10513499, Compound 11 | US11254644, Compound 11 ...)
Affinity DataIC50:  99nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50247642(CHEMBL4072240)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant TNKS2 by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468272(CHEMBL4293376)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007583(CHEBI:62882 | CHEMBL562310)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261602(US10513499, Compound 13 | US11254644, Compound 13 ...)
Affinity DataIC50:  151nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50468270(CHEMBL3344061)
Affinity DataIC50:  180nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497558(CHEMBL3344065)
Affinity DataIC50:  181nMAssay Description:Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human TNKS-2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497558(CHEMBL3344065)
Affinity DataIC50:  283nMAssay Description:Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261610(US10513499, Compound 22 | US11254644, Compound 22 ...)
Affinity DataIC50:  316nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  685nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)
Affinity DataIC50:  707nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50497559(CHEMBL3344072)
Affinity DataIC50:  832nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50061907((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261603(US10513499, Compound 14 | US11254644, Compound 14 ...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50247648(CHEMBL4082726)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261555(US10513499, Compound 10 | US11254644, Compound 10 ...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50247652(CHEMBL4093002)
Affinity DataIC50:  3.35E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-amino-3-carboxymuconate-6-semialdehyde decarboxylase(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50247643(CHEMBL1082811)
Affinity DataIC50:  4.45E+3nMAssay Description:Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50007582(CHEMBL3238252)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PARP-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A1(Rattus norvegicus (rat))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant rat CYP3A1 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM261607(US10513499, Compound 18 | US11254644, Compound 18 ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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