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Found 246 with Last Name = 'marathe' and Initial = 'ph'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20655(N-benzyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Affinity DataIC50:  0.400nM EC50:  9.60nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20645(ethyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amin...)
Affinity DataIC50:  0.900nM EC50:  37nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20650(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  0.900nM EC50:  30nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20640(methyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]ami...)
Affinity DataIC50:  1.10nM EC50:  160nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20666(propan-2-yl N-(4-{[5-(methoxycarbamoyl)-2-methylph...)
Affinity DataIC50:  1.20nM EC50:  110nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20656(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  1.20nM EC50:  2.40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20665(ethyl N-(4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)
Affinity DataIC50:  1.5nM EC50:  26nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235904(CHEMBL439238 | N-(R)-sec-butyl-6-(4-(2-fluoropheny...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236476(CHEMBL255482 | N-(5-(ethylcarbamoyl)-2-methylpheny...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20653(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-N-(...)
Affinity DataIC50:  2.20nM EC50:  140nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20657(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)
Affinity DataIC50:  2.20nM EC50:  10nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236483((S)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235905(CHEMBL255469 | N-(S)-sec-butyl-6-(4-(2-fluoropheny...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50348884(CHEMBL1807448)
Affinity DataIC50:  3nMAssay Description:Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50348883(CHEMBL1807447)
Affinity DataIC50:  3nMAssay Description:Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20652(N-[(2S)-butan-2-yl]-4-{[5-(methoxycarbamoyl)-2-met...)
Affinity DataIC50:  3nM EC50: <2nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20649(N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]am...)
Affinity DataIC50:  3.10nM EC50:  61nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20649(N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]am...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235895(6-(5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl)-N-(...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236490(CHEMBL257995 | N-(5-carbamoyl-2-methylphenyl)-2-(i...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235907(6-(4-(2-fluorophenyl)-1H-imidazol-5-yl)-N-isopropy...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20664(methyl N-(4-{[5-(methoxycarbamoyl)-2-methylphenyl]...)
Affinity DataIC50:  3.30nM EC50:  100nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235907(6-(4-(2-fluorophenyl)-1H-imidazol-5-yl)-N-isopropy...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236474(CHEMBL255698 | N-(5-(ethylcarbamoyl)-2-methylpheny...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236473((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236475(2-(isopropylamino)-N-(2-methyl-5-(methylcarbamoyl)...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20660(3-({6-acetamido-5-methylpyrrolo[1,2-a][1,2,4]triaz...)
Affinity DataIC50:  3.60nM EC50:  190nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235896(6-(5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl)-N-i...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236487(2-(isopropylamino)-N-(5-(isoxazol-3-ylcarbamoyl)-2...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50327020(4-(5-(Isoxazol-3-ylcarbamoyl)-2-methylphenylamino)...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50348880(CHEMBL1807446)
Affinity DataIC50:  4nMAssay Description:Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20643(methyl 4-{[5-(ethoxycarbamoyl)-2-methylphenyl]amin...)
Affinity DataIC50:  4nM EC50:  380nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236488(CHEMBL257994 | N-(5-carbamoyl-2-methylphenyl)-2-(p...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236478(CHEMBL255288 | N-(5-((1H-pyrazol-5-yl)carbamoyl)-2...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236480(CHEMBL257996 | N-(2-methyl-5-(methylcarbamoyl)phen...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20673(ethyl N-(3-{[6-(ethylcarbamoyl)-5-methylpyrrolo[1,...)
Affinity DataIC50:  4.70nM EC50:  72nMAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM28569(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50348912(CHEMBL1807591)
Affinity DataIC50:  5nMAssay Description:Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50236485(2-(isopropylamino)-N-(2-methyl-5-((1-methyl-1H-pyr...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235894(6-(5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl)-N-(...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20668(ethyl N-(4-methyl-3-{[5-methyl-6-(propylcarbamoyl)...)
Affinity DataIC50:  5.5nM EC50:  69nMpH: 7.5 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20675(ethyl N-[3-({6-[(2S)-butan-2-ylcarbamoyl]-5-methyl...)
Affinity DataIC50:  5.60nM EC50:  47nMAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50348885(CHEMBL1807439)
Affinity DataIC50:  6nMAssay Description:Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM28545(N,12-dimethyl-4-phenyl-5-thia-3,7,10,12-tetraazatr...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235899(6-(4-(2-fluorophenyl)oxazol-5-yl)-N-isopropylbenzo...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235901(CHEMBL255268 | N-(R)-sec-butyl-6-(4-(2-fluoropheny...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50348886(CHEMBL1807442)
Affinity DataIC50:  7nMAssay Description:Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50235911(CHEMBL256925 | N-isopropyl-6-(4-phenyl-1H-imidazol...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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