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Found 488 with Last Name = 'mederski' and Initial = 'ww'
TargetType-2 angiotensin II receptor(RAT)
E. Merck

Curated by ChEMBL
LigandPNGBDBM50041700(2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataKi:  300nMAssay Description:Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070888(CHEMBL298725 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  0.0320nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070884(CHEMBL48907 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  0.300nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50069575(3-Benzo[1,2,5]thiadiazol-5-yl-5-hydroxy-5-(4-metho...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of [125I]-ET-1 binding to rat aorta membrane Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50285171(2-{2,6-Dioxo-4-propyl-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  0.650nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285833(1N,1N-dimethyl-2-(2-butyl-4-oxo-3-{4-[2-(1H-1,2,3,...)
Affinity DataIC50:  0.700nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070886(CHEMBL51234 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  1nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50041701(2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity against AT1 receptor in the presence of 0.01% BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50034263(CHEMBL25438 | PD-156707 | Sodium; (Z)-2-benzo[1,3]...)
Affinity DataIC50:  1.30nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50041688(CHEMBL43500 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity against AT1 receptor of rat adrenal cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070881(CHEMBL295483 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  1.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50285164(1-Cyclohexyl-3-(2-{2,6-dioxo-4-propyl-3-[2'-(1H-te...)
Affinity DataIC50:  1.40nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  1.5nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50406795(Cozaar | LOSARTAN POTASSIUM)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity against AT1 receptor in the presence of 0.01% BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50041689(5-Benzyl-2-butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  1.70nMAssay Description:Binding affinity against AT1 receptor of rat adrenal cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50282613(6-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50403242(CHEMBL2079790)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50403245(CHEMBL2079788)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50403247(CHEMBL2079791)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50403246(CHEMBL2079787)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285165(2-{2,6-Dioxo-4-propyl-3-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  2.30nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285163(2-{4-Butyl-2,6-dioxo-3-[2'-(1H-tetrazol-5-yl)-biph...)
Affinity DataIC50:  2.40nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285818(2-Butyl-5-(2-morpholin-4-yl-2-oxo-1-phenyl-ethyl)-...)
Affinity DataIC50:  2.90nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285832(2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50041683(2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  3nMAssay Description:Binding affinity against AT1 receptor in the presence of 0.01% BSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50403243(CHEMBL2079789)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070882((Z)-2-Benzo[1,2,5]thiadiazol-5-yl-4-(2-fluoro-4-me...)
Affinity DataIC50:  3nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50282616(6-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285820(CHEMBL88663 | {2-Ethyl-4-oxo-3-[2'-(1H-tetrazol-5-...)
Affinity DataIC50:  3.10nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285829(CHEMBL314603 | {4-Oxo-2-propyl-3-[2'-(1H-tetrazol-...)
Affinity DataIC50:  3.10nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285166(3-Allyl-6-propyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  3.30nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070877(CHEMBL262000 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  3.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070871(CHEMBL431160 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  3.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070890(CHEMBL51890 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol...)
Affinity DataIC50:  3.40nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50285160(CHEMBL292781 | N-(2-{2,6-Dioxo-4-propyl-3-[2'-(1H-...)
Affinity DataIC50:  3.40nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50075421(7-(Ethyl-methanesulfonyl-amino)-1-(2-methoxy-benzy...)
Affinity DataIC50:  3.60nMAssay Description:Ability to displace [125I]-Endothelin-1 from endothelin B receptor in porcine kidney membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50285834(2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  3.60nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50450370(CHEMBL313691)
Affinity DataIC50:  3.70nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(RAT)
Merck

Curated by ChEMBL
LigandPNGBDBM50070873(CHEMBL301577 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  3.70nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50285813(CHEMBL316063 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5...)
Affinity DataIC50:  4nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50282611((3-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
TBA

Curated by ChEMBL
LigandPNGBDBM50403244(CHEMBL2079785)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 induced contractions in isolated rabbit aortic ringsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285821(2-Butyl-5-(2-oxo-1-phenyl-propyl)-3-[2'-(1H-tetraz...)
Affinity DataIC50:  4.10nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285816(2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  4.20nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285177(6-Propyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  4.30nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285835(2-Butyl-5-(2-oxo-1-phenyl-2-piperidin-1-yl-ethyl)-...)
Affinity DataIC50:  4.40nMAssay Description:In vitro binding affinity determined against angiotensin II AT1 receptor in rat adrenal cortex preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50285173(2-(2-{2,6-Dioxo-4-propyl-3-[2'-(1H-tetrazol-5-yl)-...)
Affinity DataIC50:  4.40nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50285167(6-Butyl-3-methyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  4.5nMAssay Description:Tested for binding affinity against angiotensin II receptor in rat adrenal cortexMore data for this Ligand-Target Pair
In DepthDetails Article
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