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Target
Type-1 angiotensin II receptor
Ligand
BDBM50282613
Substrate
n/a
Meas. Tech.
ChEMBL_34647 (CHEMBL648938)
IC50
2±n/a nM
Citation
 Dorsch, D; Mederski, WW; Beier, N; Lues, I; Minck, K; Schelling, P (6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists Bioorg Med Chem Lett 4:1297-1302 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50282613
Synonyms:
6-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazol-5-yl}-5-methyl-4,5-dihydro-2H-pyridazin-3-one | CHEMBL24224
Type:
Small organic molecule
Emp. Form.:
C29H26N8O
Mol. Mass.:
502.5697
SMILES:
CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1 |c:6|
Structure:
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