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Found 91 with Last Name = 'medhurst' and Initial = 'sj'
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417280(CHEMBL1271548)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416599(CHEMBL1222821)
Affinity DataIC50:  1.58nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417274(CHEMBL1269248)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416380(CHEMBL1210561)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417273(CHEMBL1271885)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416375(CHEMBL1210623)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416378(CHEMBL1210563)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416603(CHEMBL1222883)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416603(CHEMBL1222883)
Affinity DataIC50:  3.16nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417278(CHEMBL1271767)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417279(CHEMBL1271884)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417272(CHEMBL1271604)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417271(CHEMBL1271769)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417270(CHEMBL1271656)
Affinity DataIC50:  5.01nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416598(CHEMBL1222820)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50189987(6-phenyl-N-(quinolin-7-yl)nicotinamide | CHEMBL213...)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity against human TRPV1 assessed as inhibition of acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416383(CHEMBL1210558)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416383(CHEMBL1210558)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416383(CHEMBL1210558)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  9nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by whole cell patch clamp a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416377(CHEMBL1210621)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416379(CHEMBL1210562)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416395(CHEMBL1210369)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417268(CHEMBL1271826)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417269(CHEMBL1269250)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417277(CHEMBL1269249)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417275(CHEMBL1271939)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416618(CHEMBL1222819)
Affinity DataIC50:  12.6nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416390(CHEMBL1210439)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416376(CHEMBL1210622)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417267(CHEMBL1271768)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415882(CHEMBL1094106)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417266(CHEMBL1271655)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417265(CHEMBL1271708)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416610(CHEMBL1222673)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417276(CHEMBL1269330)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416602(CHEMBL1222882)
Affinity DataIC50:  31.6nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417264(CHEMBL1271605)
Affinity DataIC50:  31.6nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416607(CHEMBL1222669)
Affinity DataIC50:  31.6nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415883(CHEMBL1095454)
Affinity DataIC50:  39.8nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416382(CHEMBL1210559)
Affinity DataIC50:  39.8nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  40nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx by whole cell patch clamp ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Cavia porcellus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  63nMpH: 5.3Assay Description:Antagonist activity at guinea pig TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416386(CHEMBL1210500)
Affinity DataIC50:  63.1nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417275(CHEMBL1271939)
Affinity DataIC50:  63.1nMAssay Description:Antagonist activity at rat recombinant P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416381(CHEMBL1210560)
Affinity DataIC50:  63.1nMAssay Description:Antagonist activity at human P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416613(CHEMBL1222739)
Affinity DataIC50:  79.4nMAssay Description:Inhibition of human P2X7 receptor by ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416383(CHEMBL1210558)
Affinity DataIC50:  79.4nMAssay Description:Antagonist activity at rat P2X7 receptor ethidium bromide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50416383(CHEMBL1210558)
Affinity DataIC50:  79.4nMAssay Description:Antagonist activity at rat recombinant P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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