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Found 40 with Last Name = 'medveczky' and Initial = 'm'
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50366681(BRIVUDINE | BVDU | Bridic | Brivox | Brivudin | Br...)
Affinity DataKi:  240nMAssay Description:Inhibition of Herpes simplex virus 1 recombinant thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50132292(5-Ethyl-1-((2R,5R)-4-hydroxy-5-hydroxymethyl-tetra...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034949(2-Amino-6-(3,5-dichloro-phenylamino)-3H-pyrimidin-...)
Affinity DataIC50:  770nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034950(2-Amino-6-(3,4-dichloro-phenylamino)-3H-pyrimidin-...)
Affinity DataIC50:  850nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50:  850nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  880nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034947(2-(3,5-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  910nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034963(CHEMBL51501 | N*2*-(3,5-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50:  920nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21877(2,9-disubstituted 6-oxopurine, 12a | 9-[4-(dimethy...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50370388(5IUDR | Allergan 211 | Allergan-211 | Dendrid | He...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034952(6-(3,5-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50132298(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahyd...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50028342(6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50375780(CHEMBL408518)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50210810(2-(3-Trifluoromethyl-phenylamino)-1,9-dihydro-puri...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM1(dT | thymidine)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50375778(CHEMBL221982)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21866(2-phenylamino-9-(4-hydroxybutyl)-6-oxopurine | 9-(...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50375781(CHEMBL261850)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50366681(BRIVUDINE | BVDU | Bridic | Brivox | Brivudin | Br...)
Affinity DataIC50:  3.23E+4nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50375779(CHEMBL261325)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50210804(2-Amino-9-(4-hydroxy-3-hydroxymethyl-butyl)-1,9-di...)
Affinity DataIC50:  8.44E+4nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against coupled primase-DNA polymerase I assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against coupled primase-DNA polymerase I assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50021776(2-Amino-9-(2-hydroxy-ethoxymethyl)-5,9-dihydro-pur...)
Affinity DataIC50:  1.22E+5nMAssay Description:Inhibition of Herpes simplex virus 1 recombinant thymidine kinaseMore data for this Ligand-Target Pair
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21868(2-amino-9-(4-hydroxybutyl)-6,9-dihydro-3H-purin-6-...)
Affinity DataIC50:  1.77E+5nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 2)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50021776(2-Amino-9-(2-hydroxy-ethoxymethyl)-5,9-dihydro-pur...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Herpes simplex virus 2 recombinant thymidine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM85707(CAS_82410-32-0 | DHPG | NSC_3454)
Affinity DataIC50:  8.00E+5nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Affinity DataIC50:  9.00E+5nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Macacine herpesvirus 1)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50021776(2-Amino-9-(2-hydroxy-ethoxymethyl)-5,9-dihydro-pur...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed