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Found 457 with Last Name = 'miller' and Initial = 'mt'
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50241504(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
University Of California

Curated by ChEMBL
LigandPNGBDBM50236983(2-Hydroxy-cyclohepta-2,4,6-trienone | 2-hydroxycyc...)
Affinity DataIC50:  400nMAssay Description:Inhibition of mushroom tyrosinase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278741(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335802(4-Fluoro-N-(8-hydroxyquinolin-7-yl)benzenesulfonam...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278742(3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335803(3-hydroxy-2-methyl-4H-pyran-4-thione | CHEMBL16506...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of mushroom tyrosinase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335813(CHEMBL1650642 | N-(8-Hydroxyquinolin-7-yl)-[1,1-bi...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335814(CHEMBL1650643 | N-(8-Hydroxyquinolin-7-yl)thiophen...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335807(CHEMBL1650640 | N-(8-Hydroxyquinolin-7-yl)benzenes...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278743(AM-2S | CHEMBL470194 | N-(biphenyl-4-ylmethyl)-3-h...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335805(4-Fluoro-N-(8-hydroxyquinolin-5-yl)benzenesulfonam...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335812(CHEMBL1650639 | N-(8-Hydroxyquinolin-5-yl)thiophen...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335804(CHEMBL1650636 | N-(8-Hydroxyquinolin-5-yl)benzenes...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50241504(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of human MMP2 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335801(CHEMBL1650638 | N-(8-Hydroxyquinolin-5-yl)-[1,1'-b...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335803(3-hydroxy-2-methyl-4H-pyran-4-thione | CHEMBL16506...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant 5-lipoxygenase after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278812(5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid (bip...)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278813(5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid 4-me...)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278812(5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid (bip...)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of human MMP2 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278740(3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic ...)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of human MMP3 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278740(3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic ...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human MMP2 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278814(CHEMBL498272 | N-(biphenyl-4-ylmethyl)-5-hydroxy-2...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human MMP2 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278070(5-Hydroxy-2-methyl-4-thioxo-4H-pyran-3-carboxylic ...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human MMP2 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278740(3-Hydroxy-6-methyl-4-thioxo-4H-pyran-2-carboxylic ...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human MMP1 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278130(2-{[(Biphenyl-4-ylmethyl)-amino]-methyl}-3-hydroxy...)
Affinity DataIC50:  3.77E+4nMAssay Description:Inhibition of human MMP2 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50278812(5-Hydroxy-4-thioxo-4H-pyran-2-carboxylic acid (bip...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human MMP1 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50241504(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxylic aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human MMP1 catalytic domain by fluorescent substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335808(2,5-Dihydroxybenzoate, VI | 2,5-dihydroxybenzoic a...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of human recombinant 5-lipoxygenase after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335806(3-hydroxy-4H-pyran-4-thione | CHEMBL1649594)
Affinity DataIC50:  7.60E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
University Of California

Curated by ChEMBL
LigandPNGBDBM26193(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of mushroom tyrosinase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335810(2-thiouracil | 4-mercaptopyrimidin-2-ol | CHEMBL16...)
Affinity DataIC50:  1.21E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50236983(2-Hydroxy-cyclohepta-2,4,6-trienone | 2-hydroxycyc...)
Affinity DataIC50:  1.46E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335809(6-hydroxypicolinic acid | CHEMBL1650602)
Affinity DataIC50:  1.59E+5nMAssay Description:Inhibition of mushroom tyrosinase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
University Of California

Curated by ChEMBL
LigandPNGBDBM50335806(3-hydroxy-4H-pyran-4-thione | CHEMBL1649594)
Affinity DataIC50:  2.04E+5nMAssay Description:Inhibition of recombinant anthrax lethal factor after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50335811(3-amino-2-hydroxybenzoic acid | CHEMBL1650630)
Affinity DataIC50:  3.89E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
University Of California

Curated by ChEMBL
LigandPNGBDBM50099857(ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsae...)
Affinity DataIC50:  1.14E+7nMAssay Description:Inhibition of recombinant anthrax lethal factor after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50099857(ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsae...)
Affinity DataIC50:  1.50E+7nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281046(US10022352, Compound 307)
Affinity DataEC50:  981nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281047(US10022352, Compound 308)
Affinity DataEC50:  3.10E+3nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281048(US10022352, Compound 309)
Affinity DataEC50:  38.1nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281049(US10022352, Compound 310 | US10022352, Compound 31...)
Affinity DataEC50:  160nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281050(US10022352, Compound 311)
Affinity DataEC50:  81.8nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281051(US10022352, Compound 312)
Affinity DataEC50:  181nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281052(US10022352, Compound 313)
Affinity DataEC50:  284nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281053(US10022352, Compound 314)
Affinity DataEC50:  228nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281054(US10022352, Compound 315)
Affinity DataEC50:  272nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281055(US10022352, Compound 316)
Affinity DataEC50:  285nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281056(US10022352, Compound 317)
Affinity DataEC50:  4.53E+3nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281049(US10022352, Compound 310 | US10022352, Compound 31...)
Affinity DataEC50:  65.9nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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