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Found 287 with Last Name = 'moreira' and Initial = 'r'
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303364(1-(4-((Benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303371(1-(6-((Benzo[d]thiazol-2-ylthio)methyl)pyridin-3-y...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM234270(4-oxo-β-lactam (3))
Affinity DataKi:  0.630nM ΔG°:  -52.5kJ/moleT: 2°CAssay Description:The inhibition of the HLE was studied at 25°C by continuously monitoring the absorbance at 410 nm for 20 min of a solution prepared by mixing 10 _...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235615(3,3-diethyl-1-(4-methoxyphenyl)azetidine-2,4-dione...)
Affinity DataKi:  0.710nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303369(1-(4-((Benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3...)
Affinity DataKi:  0.820nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303373(3-butyl-3-ethyl-1-phenylazetidine-2,4-dione | CHEM...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303363(2-(4-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)benzylthi...)
Affinity DataKi:  1nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303370(1-(4-((5-Phenyl-1,3,4-oxadiazol-2-ylthio)methyl)ph...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235613(3,3-diethyl-1-phenylazetidine-2,4-dione | CHEMBL27...)
Affinity DataKi:  1.21nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303357(3,3-Diethyl-1-(6-methylpyridin-3-yl)azetidine-2,4-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303372(3,3-Diethyl-1-(4-((phenylthio)methyl)phenyl)azetid...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303356(3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione | ...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303361(3-Ethyl-3-isobutyl-1-phenylazetidine-2,4-dione | C...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303365(1-(2-((Benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235616(1-(4-chlorophenyl)-3,3-dimethylazetidine-2,4-dione...)
Affinity DataKi:  23.8nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303358(3,3-Diethyl-1-(naphthalen-1-yl)azetidine-2,4-dione...)
Affinity DataKi:  33.9nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235610(1-benzyl-3,3-dimethylazetidine-2,4-dione | CHEMBL5...)
Affinity DataKi:  34.4nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235611(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile...)
Affinity DataKi:  63.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303362(1-(2-((Benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3...)
Affinity DataKi:  99.3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303359(1-benzyl-3,3-diethylazetidine-2,4-dione | CHEMBL27...)
Affinity DataKi:  114nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303374(3-Benzyl-3-ethyl-1-phenylazetidine-2,4-dione | CHE...)
Affinity DataKi:  127nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)TBA
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataKi:  200nMAssay Description:Binding affinity to Mycobacterium tuberculosis InhAMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303368(1-(2-((1-Methyl-1H-imidazol-2-ylthio)methyl)phenyl...)
Affinity DataKi:  203nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303360(CHEMBL271820 | ethyl 2-(3,3-Diethyl-2,4-dioxoazeti...)
Affinity DataKi:  219nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303355(3,3-Diethyl-1-o-tolylazetidine-2,4-dione | CHEMBL5...)
Affinity DataKi:  233nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303366(3-Benzyl-3-methyl-1-phenylazetidine-2,4-dione | CH...)
Affinity DataKi:  4.45E+3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235611(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile...)
Affinity DataKi:  6.35E+4nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  2nMAssay Description:Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by spectrofluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetPapain(Carica papaya)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  7nMAssay Description:Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50117291(CHEMBL3613587)
Affinity DataIC50:  8nMAssay Description:Inhibition of Trypanosoma cruzi catalytic activity of cruzain using Z-FR-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058809(CHEMBL3329524)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50393871(CHEMBL2158234)
Affinity DataIC50:  30nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-aminomethylcoumarin as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50114613((1E)-1-(3-bromophenyl)propan-1-one thiosemicarbazo...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine pre-incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50114613((1E)-1-(3-bromophenyl)propan-1-one thiosemicarbazo...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate and measured at 12 sec interval for 5 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50058806(CHEMBL3329519)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50393873(CHEMBL2158132)
Affinity DataIC50:  40nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-aminomethylcoumarin as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50114653((1E)-1-(3,4-dichlorophenyl)ethan-1-one thiosemicar...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Trypanosoma cruzi Cruzain using Z-FR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  59.1nMAssay Description:Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin releaseMore data for this Ligand-Target Pair
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50330929(2-[(p-Methylphenyl)thiopropylidenehydrazinyl]-5-me...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine pre-incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50117285(CHEMBL3613583)
Affinity DataIC50:  70nMAssay Description:Inhibition of Trypanosoma cruzi catalytic activity of cruzain using Z-FR-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444295(CHEMBL3093806)
Affinity DataIC50:  80nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universidade Federal De Pernambuco

Curated by ChEMBL
LigandPNGBDBM50114653((1E)-1-(3,4-dichlorophenyl)ethan-1-one thiosemicar...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Trypanosoma cruzi cruzaine pre-incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50609885(CHEMBL5273046)
Affinity DataIC50:  100nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50099010((S)-3-Fluoromethyl-7-methoxy-5,5,8-trioxo-5lambda*...)
Affinity DataIC50:  110nMAssay Description:Second-order rate constant for the inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444297(CHEMBL3093815)
Affinity DataIC50:  110nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain-2(Plasmodium falciparum)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  112nMAssay Description:Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50609892(CHEMBL5291291)
Affinity DataIC50:  130nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
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