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Found 1367 with Last Name = 'pan' and Initial = 'z'
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508392(CHEMBL4435664)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50584720(CHEMBL5088153)
Affinity DataKi:  1nMAssay Description:Binding affinity to TrkC (unknown origin) assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50584720(CHEMBL5088153)
Affinity DataKi:  1nMAssay Description:Binding affinity to TrkB (unknown origin) assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50584720(CHEMBL5088153)
Affinity DataKi:  1nMAssay Description:Binding affinity to TrkA (unknown origin) assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508386(CHEMBL4450627)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508391(CHEMBL4470305)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512334(CHEMBL4458344)
Affinity DataKi:  5.80nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataKi:  6.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50584720(CHEMBL5088153)
Affinity DataKi:  8nMAssay Description:Binding affinity to TrkA G595R mutant (unknown origin) assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508381(CHEMBL4454565)
Affinity DataKi:  9.40nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50584720(CHEMBL5088153)
Affinity DataKi:  11nMAssay Description:Binding affinity to TrkA G667C mutant (unknown origin) assessed as inhibition constant by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50537983(CHEMBL4646281)
Affinity DataKi:  13nMAssay Description:Binding affinity to ITK (unknown origin) using TK as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)
Affinity DataKi:  14nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50537995(CHEMBL4639739)
Affinity DataKi:  20nMAssay Description:Binding affinity to ITK (unknown origin) using TK as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508382(CHEMBL4533508)
Affinity DataKi:  27nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512336(CHEMBL4469900)
Affinity DataKi:  34nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508390(CHEMBL4445411)
Affinity DataKi:  51nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508407(CHEMBL4543011)
Affinity DataKi:  55nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)
Affinity DataKi:  97nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50537961(CHEMBL4638993)
Affinity DataKi:  110nMAssay Description:Binding affinity to ITK (unknown origin) using TK as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508389(CHEMBL4444559)
Affinity DataKi:  201nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50300205(7,8-Dimethoxy-5-methyl-1H-benzo[e]isoindole-1,3(2H...)
Affinity DataKi:  259nMAssay Description:Inhibition of human recombinant GSK3-beta at 1 uM by ATP competitive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410910(CHEMBL377651)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410912(CHEMBL379174)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410910(CHEMBL377651)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410912(CHEMBL379174)
Affinity DataKi:  4.03E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410910(CHEMBL377651)
Affinity DataKi:  6.20E+3nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410911(CHEMBL377737)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410911(CHEMBL377737)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410911(CHEMBL377737)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410912(CHEMBL379174)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50486237(3,4-Dihydroxy-Benzoic Acid Heptyl Ester | HEPTYL 3...)
Affinity DataKi:  1.35E+5nMAssay Description:Inhibition of Agaricus bisporus (mushroom) tyrosinase using L-DOPA as substrate by secondary plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50486238(3,4-Dihydroxy-Benzoic Acid Hexyl Ester | HEXYL 3,4...)
Affinity DataKi:  3.89E+5nMAssay Description:Inhibition of Agaricus bisporus (mushroom) tyrosinase using L-DOPA as substrate by secondary plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  0.0250nMAssay Description:Competitive binding affinity to EGFR (unknown origin) ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508411(CHEMBL4473956)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508403(CHEMBL4464668)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508386(CHEMBL4450627)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50508383(CHEMBL4463109)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system in presence of 6 uM ATP by HTRF assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1774(US10894048, Ref. Ex Comp. 1 | US8476284, 13)
Affinity DataIC50: <0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)
Affinity DataIC50: <0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50512346(CHEMBL4464404)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)
Affinity DataIC50: <0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM181017(US9133201, 6)
Affinity DataIC50:  0.520nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM97673(US8476284, 41 | US8497277, 6)
Affinity DataIC50:  0.520nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM97673(US8476284, 41 | US8497277, 6)
Affinity DataIC50:  0.520nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50575048(CHEMBL4866267)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of N-terminal GST fusion tagged human FGFR4 cytoplasmic domain (460 to 802 end residues) expressed in baculovirus expression system preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM97677(US8476284, 7 | US8497277, 7 | US9133201, 7)
Affinity DataIC50:  0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM97672(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Affinity DataIC50:  0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)
Affinity DataIC50:  0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails US Patent
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