BindingDB PrimarySearch_ki

Found 730 with Last Name = 'poy' and Initial = 'f'

Histone acetyltransferase p300(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542055(CHEMBL4636118 | US11274090, Example 22 Isomer 2)

IC50: <0.5nMAssay Description:Binding affinity to recombinant full length EP300 (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Histone acetyltransferase p300(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2)

IC50: <0.5nMAssay Description:Binding affinity to recombinant full length EP300 (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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3D Structure (crystal)

Tyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Psl Research University

Curated by ChEMBL

PNG

BDBM50466393(CHEMBL4277499)

IC50: 0.770nMAssay Description:Inhibition of recombinant His-tagged human Axl (473 to end residues) cytoplasmic domain expressed in insect system using poly (Glu-Ala-Tyr) peptide a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Histone acetyltransferase p300(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542046(CHEMBL4633516 | US11414384, Example 84 Isomer 2)

IC50: 2.5nMAssay Description:Binding affinity to recombinant full length EP300 (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
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CREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2)

IC50: 2.90nMAssay Description:Binding affinity to recombinant full length CBP (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by sc...More data for this Ligand-Target Pair

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Bromodomain testis-specific protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRDT BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5B(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM195608(CPI-455)

IC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Bromodomain testis-specific protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRDT BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Bromodomain-containing protein 2(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 2(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5B(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM195608(CPI-455)

IC50: 3nMAssay Description:Inhibition of KDM5B (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Bromodomain-containing protein 3(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 3(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 3nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair

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CREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542046(CHEMBL4633516 | US11414384, Example 84 Isomer 2)

IC50: 3.20nMAssay Description:Binding affinity to recombinant full length CBP (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by sc...More data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503407(CHEMBL4440829)

IC50: 4nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503399(CHEMBL4441257)

IC50: 6nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321463(6-(but-3-en-1-yl)-4-(3-(difluoromethoxy)-5-(morpho...)

IC50: 6nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321467(6-but-3-enyl-4-[3-ethyl-7-(morpholine-4-carbonyl)b...)

IC50: 6nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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CREB-binding protein(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542055(CHEMBL4636118 | US11274090, Example 22 Isomer 2)

IC50: 6.70nMAssay Description:Binding affinity to recombinant full length CBP (unknown origin) incubated for 30 mins followed by H3(1 to 21) addition and measured after 1 hr by sc...More data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50613465(CHEMBL5271336)

IC50: 7nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated ligand incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503413(CHEMBL4566599)

IC50: 7nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Histone acetyltransferase p300(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50542060(CHEMBL4641354 | US11274090, Example 33 Isomer 2)

IC50: 8.10nMAssay Description:Binding affinity to recombinant N-terminal His-tagged EP300 HAT domain (unknown origin) (1287 to 1666 residues) expressed in Escherichia coli incubat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protein polybromo-1(Homo sapiens (Human))
Constellation, A Morphosys

Curated by ChEMBL

PNG

BDBM394583(2-(6-amino-5-phenylpyridazin-3-yl)phenol | US10308...)

IC50: 8.90nMAssay Description:Inhibition of PBRM1 bromodomain 5 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

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Tyrosine-protein kinase Mer(Homo sapiens (Human))
Psl Research University

Curated by ChEMBL

PNG

BDBM50466394(CHEMBL4285809)

IC50: 9nMAssay Description:Inhibition of recombinant GST-tagged human Mer (578 to 872 residues) cytoplasmic domain expressed in Baculovirus system using poly (Glu-Ala-Tyr) pept...More data for this Ligand-Target Pair

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CREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50200375(CHEMBL3902514)

IC50: 10nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321462(6-but-3-enyl-4-[4-fluoro-3-(morpholine-4-carbonyl)...)

IC50: 10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503406(CHEMBL4463538)

IC50: 10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503404(CHEMBL4455513)

IC50: 10nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM195608(CPI-455)

IC50: 10nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM195608(CPI-455)

IC50: 10nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50533317(CHEMBL4538785)

IC50: 11nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50533317(CHEMBL4538785)

IC50: 11nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50613466(CHEMBL5283924)

IC50: 11nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated ligand incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)

IC50: 11nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50533308(CHEMBL4444632)

IC50: 13nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503408(CHEMBL4459660)

IC50: 13nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50613463(CHEMBL5277826)

IC50: 13nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated ligand incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50533308(CHEMBL4444632)

IC50: 13nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5C(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM195608(CPI-455)

IC50: 14nMAssay Description:Inhibition of KDM5C (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5C(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM195608(CPI-455)

IC50: 14nMAssay Description:Inhibition of KDM5C (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50533309(CHEMBL4464860)

IC50: 15nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Lysine-specific demethylase 5A(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50533309(CHEMBL4464860)

IC50: 15nMAssay Description:Inhibition of KDM5A (unknown origin) using ART(Kme3)QTARKSTGGKAPRKQLA-NovaTagPEG-biotin/1 uM 2-OG as substrate/co-factor by TR-FRET assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50558065(CHEMBL4780530)

IC50: 15nMAssay Description:Inhibition of His/FLAG-tagged BRD4 BD1 (unknown origin) using histone H4-TetraAcetylated-biotin peptide as substrate incubated for 20 mins by AlphaLI...More data for this Ligand-Target Pair

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3D Structure (crystal)

Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321460(3-(6-but-3-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)

IC50: 15nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503412(CHEMBL4459431)

IC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM50503398(CHEMBL4445482)

IC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321465(6-but-3-enyl-4-[3-methyl-7-(morpholine-4-carbonyl)...)

IC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Transcription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

PNG

BDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)

IC50: 16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair

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Bromodomain-containing protein 4(Homo sapiens (Human))
Constellation Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50613464(CHEMBL5278351)

IC50: 17nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated ligand incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Displayed 1 to 50 (of 730 total ) | Next | Last >>

Filter my 730 hits

Targets 44▿
- Bromodomain-containing protein 4 257
- Transcription initiation factor TFIID subunit 1 79
- CREB-binding protein/Histone acetyltransferase p300 78
- Lysine-specific demethylase 5A 44
- Bromodomain-containing protein 9 43
- Chromatin remodeling regulator CECR2 40
- CREB-binding protein 33
- Histone acetyltransferase p300 23
- Transcription activator BRG1 17
- Peregrin 15
- Protein polybromo-1 14
- Probable global transcription activator SNF2L2 13
- Histone acetyltransferase KAT2B 4
- Bromodomain adjacent to zinc finger domain protein 2B 4
- Tyrosine-protein kinase receptor TYRO3 4
- Tyrosine-protein kinase receptor UFO 4
- Tyrosine-protein kinase Mer 4
- Bromodomain-containing protein 8 4
- Transcription intermediary factor 1-alpha 4
- Nucleosome-remodeling factor subunit BPTF 3
- ATPase family AAA domain-containing protein 2 3
- Bromodomain-containing protein 3 2
- Bromodomain adjacent to zinc finger domain protein 2A 2
- Lysine-specific demethylase 2B 2
- Bromodomain-containing protein 2 2
- Lysine-specific demethylase 5B 2
- Lysine-specific demethylase 3B 2
- Lysine-specific demethylase 4C 2
- Lysine-specific demethylase 5C 2
- Histone lysine demethylase PHF8 2
- Histone acetyltransferase KAT2A 2
- Cytochrome P450 1A2 2
- Bromodomain testis-specific protein 2
- Cytochrome P450 2C9 2
- Cytochrome P450 2C19 2
- Cytochrome P450 2D6 2
- Cytochrome P450 2C8 2
- Cytochrome P450 3A4 2
- Transcription initiation factor TFIID subunit 1-like 1
- Bromodomain and PHD finger-containing protein 3 1
- Transcription initiation factor TFIID subunit 11 1
- Bromodomain-containing protein 1 1
- Potassium voltage-gated channel subfamily H member 2 1
- Cytochrome P450 2B6 1
- ...
Publications 9▿
- J Med Chem 61: 9301-9315 (2018) 177
- J Med Chem 59: 10549-10563 (2016) 167
- J Med Chem 59: 5391-402 (2016) 94
- Bioorg Med Chem Lett 26: 4350-4 (2016) 56
- J Med Chem 65: 11177-11186 (2022) 46
- ACS Med Chem Lett 4: 835-40 (2013) 44
- ACS Med Chem Lett 7: 145-50 (2016) 39
- ACS Med Chem Lett 11: 1324-1329 (2020) 31
- Bioorg Med Chem 26: 5510-5530 (2018) 12
Institutions 4▿
- Genentech 438
- Constellation Pharmaceuticals 170
- Constellation, A Morphosys 46
- Psl Research University 12
Affinity: 0.5 to 1.0E+5 nM▿
- IC50 669
- Kd 30
- EC50 31
- Affinity ≤ nM
Xtal structures: 27
Docked structures: 0
Catalog Cmpds: 23