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Found 235 with Last Name = 'richards' and Initial = 'b'
LigandPNGBDBM50223637(Alphacemethadone | Alphacetylmethadol)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223633(Levomethadone)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223637(Alphacemethadone | Alphacetylmethadol)
Affinity DataKi:  3.40nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  6nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
LigandPNGBDBM50223631(Betacetylmethadol)
Affinity DataKi:  15nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223633(Levomethadone)
Affinity DataKi:  77nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223640((S)-Methadone | CHEMBL350719)
Affinity DataKi:  110nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223639(CHEMBL171118)
Affinity DataKi:  150nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  190nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
LigandPNGBDBM50223632(Alphamethadol)
Affinity DataKi:  230nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone opiate receptor binding using rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223632(Alphamethadol)
Affinity DataKi:  230nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223631(Betacetylmethadol)
Affinity DataKi:  450nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223635(CHEMBL355396)
Affinity DataKi:  600nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223636(CHEMBL173964)
Affinity DataKi:  900nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone Opioid receptors binding using rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223634(CHEMBL1325)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223638(CHEMBL367330)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the absence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223639(CHEMBL171118)
Affinity DataKi:  2.00E+3nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223640((S)-Methadone | CHEMBL350719)
Affinity DataKi:  3.20E+3nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223635(CHEMBL355396)
Affinity DataKi:  5.00E+3nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223634(CHEMBL1325)
Affinity DataKi:  6.80E+3nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223636(CHEMBL173964)
Affinity DataKi:  1.00E+4nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone Opioid receptors binding using rat brain membrane in the presence of 100 mM NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223638(CHEMBL367330)
Affinity DataKi:  3.00E+4nMAssay Description:Compound was evaluated for the inhibition of [3H]- naloxone binding to Opioid receptors in rat brain membrane in the presence of NaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348075(CHEMBL1800705)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348068(CHEMBL1800516)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348065(CHEMBL1800513)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348085(CHEMBL1800715)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348029(CHEMBL1800426)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348074(CHEMBL1800522)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348066(CHEMBL1800514)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  20nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  25nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348038(CHEMBL1800485)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348051(CHEMBL1800498)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348054(CHEMBL1800501)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50006932(CHEMBL3237245)
Affinity DataIC50:  29nMAssay Description:Inhibition of Keap1/Nrf2 complex (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348021(CHEMBL1800418)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348049(CHEMBL1800496)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348020(CHEMBL1800417)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348052(CHEMBL1800499)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348024(CHEMBL1800421)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataIC50:  44nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348043(CHEMBL1800490)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348045(CHEMBL1800492)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348023(CHEMBL1800420)
Affinity DataIC50:  54nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50537622(CHEMBL4634168)
Affinity DataIC50:  55nMAssay Description:Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM561983(BDBM50369389 | US11396496, Compound A1)
Affinity DataIC50:  60nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM561983(BDBM50369389 | US11396496, Compound A1)
Affinity DataIC50:  63nMAssay Description:Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50130549(CHEMBL3632711)
Affinity DataIC50:  63nMAssay Description:Inhibition of Keap1 Kelch domain (unknown origin) /Nrf2 (unknown origin) interaction using fluorescein-labeled 9-mer peptide containing NRF2 Neh2 dom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50519234(CHEMBL4440989)
Affinity DataIC50:  63nMAssay Description:Inhibition of FITC-9mer Nrf2 peptide binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
The Board of Trustees of The University of Illinois

US Patent
LigandPNGBDBM561983(BDBM50369389 | US11396496, Compound A1)
Affinity DataIC50:  63nMAssay Description:The IC50 of the compounds for inhibiting the interaction of a fluorescent NRF2 peptide and the Kelch domain of KEAP1 was determined using fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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