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Found 217 with Last Name = 'rotella' and Initial = 'dp'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316949((3R)-3-((3-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302220(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316948((R)-7-[8-(2-Oxo-1,2,3,4-tetrahydro-quinolin-7-ylme...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316947(CHEMBL1087818 | N-(3-(2-(8-((2-oxo-1,2,3,4-tetrahy...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316955((R)-3-((4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  2nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  2nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316952((R)-3-((4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-ylox...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225073((S)-2-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302218(7-(1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316946(CHEMBL1087585 | N-(2-fluoro-5-(2-(8-((2-oxo-1,2,3,...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  6nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316948((R)-7-[8-(2-Oxo-1,2,3,4-tetrahydro-quinolin-7-ylme...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316946(CHEMBL1087585 | N-(2-fluoro-5-(2-(8-((2-oxo-1,2,3,...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316955((R)-3-((4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302224(7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316956(7-(4-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316957(7-(4-(3-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316958(7-(4-(2-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316954(CHEMBL1088560 | N-(3-(2-(4-((2-oxo-1,2,3,4-tetrahy...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316950(CHEMBL1087872 | N-(2-fluoro-5-(2-(4-(2-oxo-1,2,3,4...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302221(7-((1-(2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225053(2-(S)-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl...)
Affinity DataKi:  10nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316947(CHEMBL1087818 | N-(3-(2-(8-((2-oxo-1,2,3,4-tetrahy...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50378462(CHEMBL1237149)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50225049(2-(S)-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl...)
Affinity DataKi:  14nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302224(7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302223(4-(4-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316949((3R)-3-((3-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316951(CHEMBL1087745 | N-(3-(2-(4-(2-oxo-1,2,3,4-tetrahyd...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316953(CHEMBL1087743 | N-(2-fluoro-5-(2-(4-((2-oxo-1,2,3,...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]spiperone form human dopamine D2 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316954(CHEMBL1088560 | N-(3-(2-(4-((2-oxo-1,2,3,4-tetrahy...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316952((R)-3-((4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-ylox...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316953(CHEMBL1087743 | N-(2-fluoro-5-(2-(4-((2-oxo-1,2,3,...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50316951(CHEMBL1087745 | N-(3-(2-(4-(2-oxo-1,2,3,4-tetrahyd...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]citalopram form human SRET by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302214((3S)-3-((2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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