Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 4
Ligand
BDBM50225073
Substrate
n/a
Meas. Tech.
ChEMBL_450927 (CHEMBL900014)
Ki
2.9±n/a nM
Citation
Simpkins, LM; Bolton, S; Pi, Z; Sutton, JC; Kwon, C; Zhao, G; Magnin, DR; Augeri, DJ; Gungor, T; Rotella, DP; Sun, Z; Liu, Y; Slusarchyk, WS; Marcinkeviciene, J; Robertson, JG; Wang, A; Robl, JA; Atwal, KS; Zahler, RL; Parker, RA; Kirby, MS; Hamann, LG Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 17:6476-80 (2007) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103
Type:
Enzyme
Mol. Mass.:
88271.01
Organism:
Homo sapiens (Human)
Description:
P27487
Residue:
766
Sequence:
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
Inhibitor
Name:
BDBM50225073
Synonyms:
(S)-2-amino-1-(1S,5R)-2-aza-bicyclo[3.1.0]hex-2-yl-2-(3-hydroxy-5,7-dimethyl-adamantan-1-yl)-ethanone | CHEMBL391211
Type:
Small organic molecule
Emp. Form.:
C19H30N2O2
Mol. Mass.:
318.4537
SMILES:
CC12CC3(C)CC(O)(C1)CC(C2)(C3)[C@H](N)C(=O)N1CC[C@@H]2C[C@H]12 |w:1.0,3.3,TLB:12:10:8:5.3.2,13:10:8:5.3.2,THB:12:3:9.10.11:8,2:3:9:11.1.8,2:1:9:5.12.3,TEB:4:3:9:11.1.8,4:3:9.10.11:8,0:1:9:5.12.3,0:1:5:9.10.12|