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Found 899 with Last Name = 'shinkai' and Initial = 'h'
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094640(CHEMBL140640 | N-(4-Amino-2-propyl-quinolin-6-yl)-...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094650(CHEMBL434060 | N-(4-Amino-2-ethyl-quinolin-6-yl)-2...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094648(CHEMBL139776 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  1.80nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094651(CHEMBL342580 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  2.20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094638(CHEMBL337128 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  2.30nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094642(CHEMBL142454 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  2.60nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094646(CHEMBL139934 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  6.5nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094636(CHEMBL140103 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  7nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  8.20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094644(CHEMBL140519 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094639(CHEMBL142999 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  13nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094647(CHEMBL143605 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094649(CHEMBL140580 | N-(1-Amino-3-methyl-isoquinolin-7-y...)
Affinity DataKi:  37nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094637(CHEMBL139566 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  47nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094635(CHEMBL336238 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  51nMAssay Description:Compound was evaluated for its ability to displace [3H]-nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094643(CHEMBL358306 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  80nMAssay Description:Compound was evaluated for its ability to displace [3H]-nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094641(CHEMBL422641 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  82nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094645(CHEMBL143243 | N-(4-Amino-quinolin-6-yl)-2-(4-chlo...)
Affinity DataKi:  86nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094652(CHEMBL343424 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  89nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  103nMAssay Description:Inhibition of [3H]diprenorphine (0.33 nM) binding from human Opioid receptor mu 1 expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094653(CHEMBL141078 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  121nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094654(Biphenyl-2-carboxylic acid (4-amino-2-methyl-quino...)
Affinity DataKi:  369nMAssay Description:Compound was evaluated for its ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibition of [3H]naltrindole (0.55 nM) binding from human Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50094634(CHEMBL140979 | N-(4-Amino-2-methyl-quinolin-6-yl)-...)
Affinity DataKi:  8.65E+3nMAssay Description:Inhibition of [3H]naltrindole (0.55 nM) binding from human Opioid receptor delta 1 expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50428877(CHEMBL2338480)
Affinity DataIC50:  1nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183275((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50183274(6-(3-Chloro-2-fluorobenzyl)-1-(2-hydroxyethyl)-7-m...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183274(6-(3-Chloro-2-fluorobenzyl)-1-(2-hydroxyethyl)-7-m...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50428878(CHEMBL2338479)
Affinity DataIC50:  10nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50428881(CHEMBL2331773)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480416(CHEMBL549549)
Affinity DataIC50:  12nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM138031(US8871934, 624)
Affinity DataIC50:  14nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50428885(CHEMBL2331781)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50428884(CHEMBL2331786)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM138071(US8871934, 664)
Affinity DataIC50:  15nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM138069(US8871934, 662 | US8871934, 667)
Affinity DataIC50:  15nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137919(US8871934, 512 | US8871934, 533)
Affinity DataIC50:  15nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137948(US8871934, 541)
Affinity DataIC50:  15nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137949(US8871934, 542)
Affinity DataIC50:  15nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137953(US8871934, 546)
Affinity DataIC50:  15nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM138053(US8871934, 646 | US8871934, 659)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137914(US8871934, 507 | US8871934, 532)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137922(US8871934, 515 | US8871934, 534)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137947(US8871934, 540)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM137955(US8871934, 548)
Affinity DataIC50:  16nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50428854(CHEMBL1236924)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]-rosiglitazone from GST-tagged PPARgammaLBD (unknown origin) after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM137693(US8871934, 286)
Affinity DataIC50:  17nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM138057(US8871934, 650 | US8871934, 660)
Affinity DataIC50:  17nMpH: 8.0 T: 2°CAssay Description:The inhibitory action of PDHK activity was indirectly evaluated by performing a kinase reaction in the presence of a test compound and measuring the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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