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Found 1846 with Last Name = 'tam' and Initial = 'd'
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.0210nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026300(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0240nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026300(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0240nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026308(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0350nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026308(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0350nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026318(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026318(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026314(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0660nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026314(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0660nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345553(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-bromobenzoni...)
Affinity DataKi:  0.106nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345552(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-chlorobenzon...)
Affinity DataKi:  0.127nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345572(3-(2-(pyridin-2-yl)ethynyl)-5-fluorobenzonitrile |...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50160248((2S,3S)-2-[alpha-(2-Methylphenylthio)phenylmethyl]...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]nisoxetine from human NET receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345555(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrofluorob...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345550(3-(2-(2-Methylthiazol-4-yl)ethynyl)-5-nitrobenzoni...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026307(3-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026307(3-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM22166(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]cyanoimipramine from SERT in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026317(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026317(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50077906(CHEMBL3305901)
Affinity DataKi:  0.550nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345558(3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026316(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026316(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Institute For Degenerative Diseases

Curated by ChEMBL
LigandPNGBDBM50198230((S)-2-((S)-(2-iodophenoxy)(phenyl)methyl)morpholin...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]nisoxetine from NET in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026306(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.860nMAssay Description:Binding affinity against Dihydrofolate reductase Inhibitor of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026306(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.860nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345551(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrobromobe...)
Affinity DataKi:  0.930nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50199005((S)-2-((S)-(2-methoxyphenoxy)(phenyl)methyl)morpho...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]nisoxetine from human NET receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University

Curated by ChEMBL
LigandPNGBDBM22166(3-(4-iodophenyl)tropane-2-carboxylic acid methyl e...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]beta-CIT from DAT in rat caudate homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50254209((2S,3S)-2-[alpha-(2-Methylphenoxy)phenylmethyl]mor...)
Affinity DataKi:  1.02nMAssay Description:Displacement of [3H]nisoxetine from human NET receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50370475(S,S-REBOXETINE)
Affinity DataKi:  1.04nMAssay Description:Displacement of [3H]nisoxetine from human NET receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345557(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-bromofluorob...)
Affinity DataKi:  1.06nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50077924(CHEMBL3417124)
Affinity DataKi:  1.20nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.30nMAssay Description:Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50077980(CHEMBL3417117)
Affinity DataKi:  1.60nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.60nMAssay Description:Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50160633(2-methyl-6-[(5-phenylpyridin-3-yl)ethynyl]pyridine...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345556(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitroiodoben...)
Affinity DataKi:  1.84nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026304(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026304(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50077912(CHEMBL3417231)
Affinity DataKi:  2nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50077991(CHEMBL3417237)
Affinity DataKi:  2nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders

Curated by ChEMBL
LigandPNGBDBM50345554(3-(2-(2-methylthiazol-4-yl)ethynyl)-5-iodobenzonit...)
Affinity DataKi:  2.14nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50077986(CHEMBL3417111)
Affinity DataKi:  2.20nMAssay Description:Displacement of 0.1 nM [125I]CCL2 from human CCR2 expressing human U2OS cell membrane by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026313(5-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimeth...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  2.20nMAssay Description:Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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