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Found 141 with Last Name = 'tiwari' and Initial = 'ak'
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562066(CHEMBL4756661)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562067(CHEMBL4749288)
Affinity DataKi:  0.690nMAssay Description:Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as effect on intracellular calcium level by FLOU-4 dye based fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50249592(CHEMBL4061179)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50006115((R)-RETRO-THIORPHAN | (RETRO)N-(1-Mercaptomethyl-2...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of NEP 24.11 (unknown origin) by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562065(CHEMBL4745169)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in HEK293 cell membranes incubated for 60 mins by Cheng-Prusoff anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562077(CHEMBL4754992)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562078(CHEMBL98593)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562066(CHEMBL4756661)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517920(CHEMBL4572725)
Affinity DataKi:  34nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517888(CHEMBL4442842)
Affinity DataKi:  43nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in HEK293 cell membranes incubated for 60 mins by Cheng-Prusoff anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517889(CHEMBL4567560)
Affinity DataKi:  47nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50024095((R) N-(1-Mercaptomethyl-2-phenyl-ethyl)-malonamic ...)
Affinity DataKi:  210nMAssay Description:Inhibition of NEP 24.11 (unknown origin) by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562067(CHEMBL4749288)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cells by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562079(CHEMBL4776808)
Affinity DataKi:  587nMAssay Description:Inhibition of [3H]-Deltorphin 2 binding to mouse delta opioid receptor expressed in rat GH3 cell membranes by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi: >5.60E+3nMAssay Description:Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cells by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50249592(CHEMBL4061179)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562065(CHEMBL4745169)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562073(CHEMBL4786514)
Affinity DataKi: >4.00E+9nMAssay Description:Inhibition of NEP 24.11 (unknown origin) by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562071(CHEMBL319408)
Affinity DataIC50: <0.0300nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562070(CHEMBL17612)
Affinity DataIC50:  0.0540nMAssay Description:Inhibition of HIV1 protease using H-Val-Ser-Gln-Am-(L-b-naphthyl-alanine)-Pro-Ile-Val-OH as substrate by HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562072(CHEMBL4798264)
Affinity DataIC50:  0.0700nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50105397((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  0.0800nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)
Affinity DataIC50:  0.0820nMAssay Description:Inhibition of gamma secretase in HEK293 cells assessed as reduction in amyloid beta40 level incubated for 4 hrs by electrochemiluminescence detection...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50144749((S)-2-[((S)-1-Benzenesulfonyl-azetidine-2-carboxim...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50144760((S)-2-{[(S)-1-Benzenesulfonyl-N-(2,2,2-trifluoro-e...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50213021(CHEBI:63621 | Fortovase | Invirase | Ro-31-8959 | ...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of HIV1 protease using H-Val-Ser-Gln-Am-(L-b-naphthyl-alanine)-Pro-Ile-Val-OH as substrate by HPLC methodMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of TNF-induced MMP2 isolated from human HT-1080 cell medium by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of TNF-induced MMP2 isolated from human HT-1080 cell medium by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PMA-induced human skin fibroblast derived MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PMA-induced human skin fibroblast derived MMP1 by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of TNF-induced MMP2 isolated from human HT-1080 cell medium by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of PMA-induced human skin fibroblast derived MMP1 by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50072566((2R,3S)-2-Allyl-N*4*-[(S)-1-benzyl-2-(1H-indol-3-y...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human MMP3 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Toledo

Curated by ChEMBL
LigandPNGBDBM50276903(CHEMBL4171764)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EGFR1 (unknown origin) after 1 hr in presence of adenosine 5'[gamma-33P]triphosphate by microbeta microplate counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562075(CHEMBL4758323)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50:  10nMAssay Description:Inhibition of human MMP3 by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50:  11nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562069(CHEMBL4785595)
Affinity DataIC50:  11nMAssay Description:Inhibition of human MMP7 by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562068(CHEMBL4791227)
Affinity DataIC50:  12nMAssay Description:Inhibition of human MMP3 by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50290520(((R)-1-{(S)-1-[(2R,3S)-3-(2-tert-Butylsulfamoyl-et...)
Affinity DataIC50:  20nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562074(CHEMBL312911)
Affinity DataIC50:  20nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50562076(CHEMBL4783390)
Affinity DataIC50:  30nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50146642((S)-tetrahydrofuran-3-yl (2S,3R)-4-((3S,4aS,8aS)-3...)
Affinity DataIC50:  160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Lucknow University

Curated by ChEMBL
LigandPNGBDBM50208418(2-[5-((E)-2-biphenyl-4-yl-vinyl)-2-hydroxy-benzo[4...)
Affinity DataIC50:  197nMAssay Description:Displacement of [125I](BH)CCK8 from rat CCK1 after 30 mins by receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Lucknow University

Curated by ChEMBL
LigandPNGBDBM50208419(2-{2-hydroxy-5-[(E)-2-(4-hydroxy-phenyl)-vinyl]-be...)
Affinity DataIC50:  665nMAssay Description:Displacement of [125I](BH)CCK8 from rat CCK1 after 30 mins by receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Lucknow University

Curated by ChEMBL
LigandPNGBDBM50208420(2-[2-hydroxy-5-((E)-styryl)-benzo[4,5]imidazo[1,2-...)
Affinity DataIC50:  942nMAssay Description:Displacement of [125I](BH)CCK8 from rat CCK1 after 30 mins by receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM50072064(5-Chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

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