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Found 257 with Last Name = 'wållberg' and Initial = 'a'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191127(2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine ...)
Affinity DataIC50:  5nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395803(CHEMBL2165175)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395821(CHEMBL2165191)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191139(2-(3-(3,4-dichlorophenoxy)prop-1-ynyl)-6-methylpyr...)
Affinity DataIC50:  15nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  22nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  22nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395820(CHEMBL2165192)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191149(2-methyl-6-(3-(5,6,7,8-tetrahydronaphthalen-2-ylox...)
Affinity DataIC50:  36nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191116(2-(3-(3-chlorophenylthio)prop-1-ynyl)-6-methylpyri...)
Affinity DataIC50:  43nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50365890(CHEMBL1957875)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus using DiC8-PI(4,5)P2 as substrate after 20 mins by AlphaScreen ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191124(2-methyl-6-(4-phenylpent-1-ynyl)pyridine | CHEMBL2...)
Affinity DataIC50:  59nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Affinity DataIC50:  63nMAssay Description:Inhibition of human recombinant CYP2D6-mediated 7-methoxy-4(aminomethyl)-coumarine degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataIC50:  77nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191117(2-methyl-6-(4-phenylbut-1-ynyl)pyridine | CHEMBL21...)
Affinity DataIC50:  78nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50182823(4-(3,4-dichlorophenylthio)-2-(5-fluoropyridin-2-yl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191146(2-(3-(4-isopropylphenoxy)prop-1-ynyl)-6-methylpyri...)
Affinity DataIC50:  83nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393999(CHEMBL2158437)
Affinity DataIC50:  84nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus using DiC8-PI(4,5)P2 as substrate after 20 mins by AlphaScreen ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50182811(4-(3,4-dichlorophenylthio)-2-(pyridin-2-yl)pyrimid...)
Affinity DataIC50:  90nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395813(CHEMBL2165180)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393984(CHEMBL2158436)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus using DiC8-PI(4,5)P2 as substrate after 20 mins by AlphaScreen ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395812(CHEMBL2165181)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191157(2-(3-(3-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)
Affinity DataIC50:  101nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191147(2-(3-(4-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)
Affinity DataIC50:  102nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191151(2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine | C...)
Affinity DataIC50:  115nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191129(2-(3-(3-chlorophenylthio)but-1-ynyl)-6-methylpyrid...)
Affinity DataIC50:  118nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395815(CHEMBL2165178)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395810(CHEMBL2165183)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393984(CHEMBL2158436)
Affinity DataIC50:  140nMAssay Description:Inhibition of PI3K p110deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  168nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110delta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191130(3-chloro-N-(3-(6-methylpyridin-2-yl)prop-2-ynyl)be...)
Affinity DataIC50:  174nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50:  180nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395802(CHEMBL2165189)
Affinity DataIC50:  195nMAssay Description:Inhibition of human PI3K p110beta-mediated AKT phosphorylation at Ser473 in MDA-MB-468 cells after 2 hrs by fluorescence microplate cytometric analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395811(CHEMBL2165182)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50182813(2-(pyridin-2-yl)-4-(4-(trifluoromethyl)phenylthio)...)
Affinity DataIC50:  210nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395809(CHEMBL2165184)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant His6-tagged PI3K p110beta expressed in baculovirus infected cells using DiC8-PI(4,5)P2 as substrate after 20 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191131(CHEMBL214823 | N-(3-(6-methylpyridin-2-yl)prop-2-y...)
Affinity DataIC50:  223nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191123(2-methyl-6-(5-phenylpent-1-ynyl)pyridine | CHEMBL3...)
Affinity DataIC50:  258nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50:  260nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191118(2-(3-(3-chlorophenoxy)but-1-ynyl)-6-methylpyridine...)
Affinity DataIC50:  281nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50428603(CHEMBL2338405)
Affinity DataIC50:  300nMAssay Description:Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191148(2-(3-fluoro-5-(3-(pyridin-2-yl)prop-2-ynyloxy)phen...)
Affinity DataIC50:  300nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191113(2-(2-(benzo[b]thiophen-2-yl)ethynyl)-6-methylpyrid...)
Affinity DataIC50:  306nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50182822(4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine ...)
Affinity DataIC50:  320nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50:  320nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM86716(CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...)
Affinity DataIC50:  330nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50179667(1-(3-bromophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50:  380nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50182819(4-(3,4-dichlorophenylthio)-2-(6-methylpyridin-2-yl...)
Affinity DataIC50:  390nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandPNGBDBM50191142(2-(3-(3-methoxyphenoxy)prop-1-ynyl)-6-methylpyridi...)
Affinity DataIC50:  397nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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