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Found 433 with Last Name = 'wells' and Initial = 's'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059171(CHEMBL3393296)
Affinity DataKi:  14nMAssay Description:Competitive inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MK2 (46-400) as substrateMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50418818(CHEMBL1796293)
Affinity DataKi:  290nMAssay Description:Competitive inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MK2 (46-400) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432188(CHEMBL2346976)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]R1881 from full length androgen receptor in human LNCAP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50432188(CHEMBL2346976)
Affinity DataKi:  5.00E+3nMAssay Description:Binding affinity to rat androgen receptor ligand binding domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364751(CHEMBL1951908)
Affinity DataIC50: <0.100nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364748(CHEMBL1952100)
Affinity DataIC50: <0.100nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364745(CHEMBL1951916)
Affinity DataIC50: <0.100nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50:  0.180nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364743(CHEMBL1951914)
Affinity DataIC50:  0.260nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50185666((R)-N-(1-(3-(3,5-difluorophenyl)-3-(4-(methylsulfo...)
Affinity DataIC50:  0.320nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50:  0.390nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364771(CHEMBL1951913)
Affinity DataIC50:  0.440nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364746(CHEMBL1951917)
Affinity DataIC50:  0.550nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364770(CHEMBL1951912)
Affinity DataIC50:  0.680nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364744(CHEMBL1951915)
Affinity DataIC50:  0.690nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364743(CHEMBL1951914)
Affinity DataIC50:  0.690nMAssay Description:Antagonist activity at CCR5 in allo T cells assessed as inhibition of MIP-1beta-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364750(CHEMBL1951906)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138321((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50:  1.40nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364752(CHEMBL1951898)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029670(CHEMBL2426277 | US10227342, Example 26)
Affinity DataIC50:  2nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364766(CHEMBL1951907)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364756(CHEMBL1951894)
Affinity DataIC50:  3.10nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364747(CHEMBL1951918)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029667(CHEMBL2426288)
Affinity DataIC50:  4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364769(CHEMBL1951911)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364755(CHEMBL1951893)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364767(CHEMBL1949696)
Affinity DataIC50:  5.40nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029685(CHEMBL3353404 | US10227342, Example 52)
Affinity DataIC50:  6nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029684(CHEMBL3353403)
Affinity DataIC50:  7nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364753(CHEMBL1951899)
Affinity DataIC50:  8.90nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364764(CHEMBL1951904)
Affinity DataIC50:  8.90nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029685(CHEMBL3353404 | US10227342, Example 52)
Affinity DataIC50:  9nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153846(4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153832(3-Fluoro-N-{4-methyl-3-[4-(thiazol-4-ylmethoxy)-be...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153848(CHEMBL184012 | N-{4-Methyl-3-[4-(pyridin-2-ylmetho...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153821(3-Fluoro-N-{4-methyl-3-[4-(pyridin-4-ylmethoxy)-be...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31993(Dipeptidyl nitrile inhibitor, 26)
Affinity DataIC50:  13nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138310((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50:  13nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)
Affinity DataIC50:  13nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138306((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50:  14nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029669(CHEMBL2426279)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364759(CHEMBL1951897)
Affinity DataIC50:  15nMAssay Description:Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50059175(CHEMBL3393298)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MK2 (46 to 400) as substrate assessed as inhibition of phosphorylation after 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138324((S)-2-(3,5-Dichloro-biphenyl-4-sulfonyl)-3-({8-[(1...)
Affinity DataIC50:  17nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50138319((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50:  18nMAssay Description:Evaluated in an functional alpha-v beta-3 antagonism assay, involving adhesion of beta3-transfected 293 cells to fibrinogen (alpha-v beta-3 293 beta3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50029670(CHEMBL2426277 | US10227342, Example 26)
Affinity DataIC50:  19nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153833(CHEMBL365688 | N-{4-Methyl-3-[4-(pyridin-2-ylmetho...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153847(3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-be...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153840(4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)
Affinity DataIC50:  20nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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