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Found 267 with Last Name = 'wuest' and Initial = 'f'
TargetNeurotensin receptor type 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50319376((S)-2-((S)-2-((S)-2-((S)-1-((S)-2-((S)-2-amino-5-g...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50376383(CHEMBL259972)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029618(4-(2-(4-methoxyphenyl)cyclopent-1-enyl)benzenesulf...)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029613(1-Methoxy-4-(2-(4-(methanesulfonyl)phenyl)cyclopen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50084631(CHEMBL3427203)
Affinity DataIC50:  5nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50:  6nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50297675(CHEMBL551148 | N-(4-fluorobenzyl)-4-(4-(methylsulf...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 2 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50029613(1-Methoxy-4-(2-(4-(methanesulfonyl)phenyl)cyclopen...)
Affinity DataIC50:  7nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  8nMAssay Description:Inhibition of COX1 in human OVCAR-3 cells assessed as reduction in PGE2 level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50096276(CHEMBL1235806)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50366159(CHEMBL1957450)
Affinity DataIC50:  15nMAssay Description:Inhibition of COX2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human COX2 assessed as PGH2 formation preincubated for 10 mins followed by addition of arachidonic acid as substrate measur...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant COX2 by fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50:  20nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266516(5-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant COX-2 by fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266515(5-(4-Chlorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 2 mins by fluoresc...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant COX2 by fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  40nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50057564(4-[5-(4-Fluoro-phenyl)-3-trifluoromethyl-pyrazol-1...)
Affinity DataIC50:  41nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  60nMAssay Description:Competitive inhibition of human recombinant COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50207446(2-(2-(2-chloro-6-fluorophenylamino)-5-methylphenyl...)
Affinity DataIC50:  60nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant COX2 by enzymatic fluorescence assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  70nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50557782(CHEMBL4800072)
Affinity DataIC50:  70nMAssay Description:Inhibition of COX1 in human OVCAR-3 cells assessed as reduction in PGE2 level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant human COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50557783(CHEMBL4784073)
Affinity DataIC50:  90nMAssay Description:Inhibition of COX1 in human OVCAR-3 cells assessed as reduction in PGE2 level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50557782(CHEMBL4800072)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant ovine COX1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266511(1-(4-Methanesulfonylphenyl)-5-phenyl-1H-[1,2,3]tri...)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of FLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266512(1-(4-Methanesulfonyl-phenyl)-5-p-tolyl-1H-[1,2,3]t...)
Affinity DataIC50:  120nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266480(1-(4-Methanesulfonylphenyl)-4-phenyl-1H-[1,2,3]tri...)
Affinity DataIC50:  150nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50492260(CHEMBL2398541)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant COX2 by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266513(5-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  170nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50339185((2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | ...)
Affinity DataIC50:  180nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266484(4-(4-Chlorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50557783(CHEMBL4784073)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant ovine COX1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50029618(4-(2-(4-methoxyphenyl)cyclopent-1-enyl)benzenesulf...)
Affinity DataIC50:  200nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266485(4-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)-1H-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50557784(CHEMBL4797035)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant ovine COX1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22360(2-(acetyloxy)benzoate | 2-(acetyloxy)benzoic acid ...)
Affinity DataIC50:  350nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22360(2-(acetyloxy)benzoate | 2-(acetyloxy)benzoic acid ...)
Affinity DataIC50:  350nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50: >360nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50266514(CHEMBL457331 | N,N-dimethyl-4-(1-(4-(methylsulfony...)
Affinity DataIC50:  360nMAssay Description:Inhibition of COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50: >360nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM50557784(CHEMBL4797035)
Affinity DataIC50:  400nMAssay Description:Inhibition of COX1 in human OVCAR-3 cells assessed as reduction in PGE2 level incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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