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Found 68 with Last Name = 'zecri' and Initial = 'fj'
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608937(1-(6-{(4M)-4-(5-Chloro-6- methyl-1H-indazol-4-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609524(CHEMBL5281254)
Affinity DataIC50:  8nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609523(CHEMBL5271997)
Affinity DataIC50:  10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608850(US11702409, Example 12a | US11702409, Example 12b)
Affinity DataIC50:  20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50:  20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608886(1-{6-[(4M)-4-(5-Chloro-6- methyl-1H-indazol-4-yl)-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608857(US11702409, Example 15a | US11702409, Example 15b)
Affinity DataIC50:  30nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608856(US11702409, Example 14)
Affinity DataIC50:  50nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608888(US11702409, Example 27a | US11702409, Example 27b)
Affinity DataIC50:  90nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608896(US11702409, Example 30a | US11702409, Example 30b)
Affinity DataIC50:  140nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608868(US11702409, Example 19a | US11702409, Example 19b)
Affinity DataIC50:  500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609519(CHEMBL5266172)
Affinity DataIC50:  500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609522(CHEMBL5291136)
Affinity DataIC50:  700nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609520(CHEMBL5269632)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
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TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50:  3.74E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609521(CHEMBL5283602)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >4.70E+3nMAssay Description:Inhibition of human ERG by manual patch clamp methodMore data for this Ligand-Target Pair
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TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50:  6.23E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
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TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
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TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at alpha-2A adrenergic receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at alpha-1A adrenergic receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at CB1 receptor (unknown origin) expressed in rat CHEM-1 cells after 15 mins by calcium flux/FLIPR assay in presence of CP55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at thromboxane A2 receptor (unknown origin) expressed in HEK293-EBNA cells after 15 mins by calcium flux/FLIPR assay in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence of 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at 5HT1A receptor (unknown origin) expressed in HeLa cells after 15 mins by calcium flux/FLIPR assay in presence of R-(+)-8-OH-DP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at muscarinic acetylcholine receptor M2 (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at D1A receptor (unknown origin) expressed in CHOK1 cells after 5 mins by HTRF cAMP immunoassay in presence of cAMP/SKF38393More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at 5HT2B receptor (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence of BW723C86More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027830(CHEMBL3338693)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027831(CHEMBL3338692)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027832(CHEMBL3338691)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027833(CHEMBL3338690)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027834(CHEMBL3338689)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027836(CHEMBL3338688)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027837(CHEMBL3338687)
Affinity DataEC50:  96nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027842(CHEMBL3338686)
Affinity DataEC50:  22nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027843(CHEMBL3338685)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027844(CHEMBL3338684)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027845(CHEMBL3338683)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027847(CHEMBL3338682)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027848(CHEMBL3338681)
Affinity DataEC50:  41nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027849(CHEMBL3338680)
Affinity DataEC50:  199nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027850(CHEMBL3338679)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027851(CHEMBL3338678)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataEC50:  34nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027852(CHEMBL3338677)
Affinity DataEC50:  470nMAssay Description:Agonist activity at human APJ receptor expressed in Chem-5 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027853(CHEMBL3338701)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50027854(CHEMBL3338700)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at APJ receptor in HEK293 cells assessed as inhibition of forskolin-induced cAMP level incubated for 5 mins prior to forskolin chall...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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