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Found 191 with Last Name = 'zeng' and Initial = 's'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283545(CHEMBL4162340)
Affinity DataKi:  2.90nMAssay Description:Reversible mixed-type inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataKi:  5.10nMAssay Description:Competitive inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 mins...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  30nMAssay Description:Binding affinity to FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  30nMAssay Description:Binding affinity to wild type BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  42nMAssay Description:Binding affinity to wild type BCR-ABL T315I mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of recombinant wild type Abl (unknown origin) in presence of [33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590371(CHEMBL5182618)
Affinity DataIC50:  0.540nMAssay Description:Binding affinity to human recombinant His-tagged full length ABL1 expressed in baculovirus expression system by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283680(CHEMBL4164470)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283674(CHEMBL4176578)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283666(CHEMBL4169845)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283675(CHEMBL4175111)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283673(CHEMBL4165967)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283543(CHEMBL4172793)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283678(CHEMBL4162971)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283671(CHEMBL4169403)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM185674(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild type Abl (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590370(K-0706 | K0706 | Sco-088 | VODOBATINIB | Vodobatin...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of wild type BCR-ABL phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <1nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50590368(IY5511 | RADOTINIB | Radotinib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cells incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283672(CHEMBL4164893)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50381853(CHEMBL2023067)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human DPP4 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283677(CHEMBL4173673)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283544(CHEMBL4173272)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283630(CHEMBL4161924)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50431782(CHEMBL2347039)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate treated with enzyme 10 mins prior to substrate addition measured after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283664(CHEMBL4161474)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283676(CHEMBL4165359)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant Abl-T315I mutant (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant FGFR1 (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283545(CHEMBL4162340)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50381855(CHEMBL2023066)
Affinity DataIC50:  2.34nMAssay Description:Inhibition of human DPP4 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50283668(CHEMBL4169618)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 to 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50381854(CHEMBL2022467)
Affinity DataIC50:  2.64nMAssay Description:Inhibition of human DPP4 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM209859(4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpip...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human DPP4 after 10 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataIC50:  4nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50243388(AT-9283 | US10981896, Compound AT9283)
Affinity DataIC50:  4nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
The First Affiliated Hospital Of Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50431785(CHEMBL2347036)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human DPP4 using Gly-Pro-AMC as substrate treated with enzyme 10 mins prior to substrate addition measured after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM185674(4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM209859(4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpip...)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type Abl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Hangzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of recombinant SRC (unknown origin) in presence of [33P]-ATP by kinase hotspot assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

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