BindingDB PrimarySearch_ki

Found 175 with Last Name = 'zeng' and Initial = 't'

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541679(CHEMBL4647465)

IC50: 0.5nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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3D Structure (crystal)

Hepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)

IC50: 1.10nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541676(CHEMBL4637493)

IC50: 1.20nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541680(CHEMBL4635115)

IC50: 1.20nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541677(CHEMBL4647629)

IC50: 1.60nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541674(CHEMBL4645385)

IC50: 2.70nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541660(CHEMBL4641822)

IC50: 3.10nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Hepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)

IC50: 4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541666(CHEMBL4633521)

IC50: 4.10nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM470454(N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxym...)

IC50: 4.20nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541662(CHEMBL4638432)

IC50: 4.5nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541673(CHEMBL4646288)

IC50: 4.5nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541678(CHEMBL4633498)

IC50: 4.60nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541690(CHEMBL4639751)

IC50: 5.10nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)

IC50: 5.20nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587010(CHEMBL5093505)

IC50: 5.70nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587011(CHEMBL5091526)

IC50: 6.20nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598252(CHEMBL5206463)

IC50: 6.60nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587009(CHEMBL5086708)

IC50: 6.80nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541675(CHEMBL4632909)

IC50: 6.90nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587008(CHEMBL5076703)

IC50: 6.90nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587012(CHEMBL5083197)

IC50: 7.30nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598249(CHEMBL5193565)

IC50: 7.90nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Hepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50190810(CHEMBL3975648)

IC50: 8.20nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541672(CHEMBL4648164)

IC50: 9nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598229(CHEMBL5209435)

IC50: 9.20nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598251(CHEMBL5182494)

IC50: 9.80nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598254(CHEMBL5169436)

IC50: 10nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598250(CHEMBL5203955)

IC50: 11nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598253(CHEMBL5200075)

IC50: 13nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587001(CHEMBL5076991)

IC50: 13nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598230(CHEMBL5198888)

IC50: 14nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598228(CHEMBL5186273)

IC50: 14nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598231(CHEMBL5194645)

IC50: 16nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587007(CHEMBL5079947)

IC50: 16nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587006(CHEMBL5080473)

IC50: 17nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Hepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50190915(CHEMBL3983663)

IC50: 17nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50587000(CHEMBL5075388)

IC50: 18nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541653(CHEMBL4640115)

IC50: 19nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Hepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50190808(CHEMBL3903767)

IC50: 19nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541661(CHEMBL4640238)

IC50: 20nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598243(CHEMBL5191795)

IC50: 20nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598246(CHEMBL5174428)

IC50: 20nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541658(CHEMBL4641558)

IC50: 21nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598245(CHEMBL5177094)

IC50: 22nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598248(CHEMBL5201005)

IC50: 22nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50586996(CHEMBL5091721)

IC50: 22nMAssay Description:Inhibition of human DHODH using dihydroorotate substrate preincubated for 30 mins followed by substrate addition by DCIP based microplate reader anal...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50598242(CHEMBL5173982)

IC50: 23nMAssay Description:Inhibition of human N-terminal SUMO-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate by DCIP based microplate read...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Hepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50190914(CHEMBL3959949)

IC50: 24nMAssay Description:Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Dihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

PNG

BDBM50541659(CHEMBL4635090)

IC50: 25nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ10 as co-substrate preincubated for 30 mins followed by substrate addition by DCIP...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Details Article PubMed

Displayed 1 to 50 (of 175 total ) | Next | Last >>

Filter my 175 hits

Targets 9▿
- Dihydroorotate dehydrogenase (quinone), mitochondrial 112
- Urease subunit beta 30
- Hepatocyte growth factor receptor 17
- Cytochrome P450 3A4 6
- Cytochrome P450 1A1 2
- Cytochrome P450 1B1 2
- Cytochrome P450 1A2 2
- Cytochrome P450 2C19 2
- Cytochrome P450 2D6 2
Publications 7▿
- J Med Chem 63: 7633-7652 (2020) 61
- Eur J Med Chem 238: (2022) 32
- Bioorg Med Chem 23: 4508-4513 (2015) 30
- J Med Chem 64: 18175-18192 (2021) 19
- Eur J Med Chem 120: 37-50 (2016) 17
- Org Med Chem Lett 2: 21 (2012) 12
- J Med Chem 60: 4062-4073 (2017) 4
Institutions 5▿
- Sichuan University 112
- Jishou University 30
- Shenyang Pharmaceutical University 17
- University of The West Indies 12
- National Yang-Ming University 4
Affinity: 0.5 to 5.0E+5 nM▿
- IC50 175
- Affinity ≤ nM
Xtal structures: 10
Docked structures: 0
Catalog Cmpds: 13