Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50541677
Substrate
n/a
Meas. Tech.
ChEMBL_1985022 (CHEMBL4618428)
IC50
1.6±n/a nM
Citation
 Zuo, Z; Liu, X; Qian, X; Zeng, T; Sang, N; Liu, H; Zhou, Y; Tao, L; Zhou, X; Su, N; Yu, Y; Chen, Q; Luo, Y; Zhao, Y Bifunctional Naphtho[2,3- J Med Chem 63:7633-7652 (2020) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50541677
Synonyms:
CHEMBL4647629
Type:
Small organic molecule
Emp. Form.:
C24H15F2N3O3
Mol. Mass.:
431.391
SMILES:
COCc1cccc(c1)-c1c(F)cc(cc1F)-n1nnc2c1C(=O)c1ccccc1C2=O
Structure:
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