Affinity DataIC50: 1.20nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of CXCL10(IP-10)-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of ERK2 (unknown origin) using kinase substrate 8 incubated for 40 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of CXCL11-induced CXCR3 mediated T-cell migrationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 122nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 123nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 155nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 164nMAssay Description:Inhibition of ERK2 (unknown origin) using kinase substrate 8 incubated for 40 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 285nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 309nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine as substrate assessed as substrate hydrolysis preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
Affinity DataIC50: 409nMAssay Description:Inhibition of SMO in mouse 3T3/HH FlashII-7 cells incubated for 36 hrs in presence of SHH by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Pharmacopeia Drug Discovery
Curated by ChEMBL
Pharmacopeia Drug Discovery
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of CXCL11-stimulated calcium release in HEK293 cells expressing recombinant human CXCR3 and chimeric G protein Gqi5More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 561nMAssay Description:Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 562nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair