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Found 84 with Last Name = 'zhang' and Initial = 'lx'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453725(CHEMBL5284183)
Affinity DataKi:  5.60nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50093374(2-(4-Hydroxy-phenyl)-1H-benzoimidazole-4-carboxyli...)
Affinity DataKi:  6nMAssay Description:Inhibition of human full length PARP1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27119(2-(1-propylpiperidin-4-yl)-1H-1,3-benzodiazole-4-c...)
Affinity DataKi:  8nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50165486(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataKi:  12nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453726(CHEMBL3919533)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50165486(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453722(CHEMBL5283272)
Affinity DataIC50:  19nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453724(CHEMBL5268593)
Affinity DataIC50:  140nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27502(3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoq...)
Affinity DataIC50:  150nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27682(5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one | CHE...)
Affinity DataIC50:  150nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453721(CHEMBL133694)
Affinity DataIC50:  240nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27500(5,6-dihydrophenanthridin-6-one | 5H-Phenanthridin-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453723(CHEMBL5283140)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50607981(CHEMBL4782984)
Affinity DataIC50:  1.70E+3nMAssay Description:Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target14-3-3 protein gamma(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383920(CHEMBL2031675)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant GST-tagged 14-3-3gamma interaction with TMR-pS259-Raf peptide after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50607983(CHEMBL1170915)
Affinity DataIC50:  2.40E+3nMAssay Description:Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target14-3-3 protein gamma(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383921(CHEMBL2031676)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of recombinant GST-tagged 14-3-3gamma interaction with TMR-pS259-Raf peptide after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50607982(CHEMBL4789502)
Affinity DataIC50:  2.90E+3nMAssay Description:Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50607984(CHEMBL4758598)
Affinity DataIC50:  6.20E+3nMAssay Description:Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50607980(CHEMBL4751648)
Affinity DataIC50:  6.70E+3nMAssay Description:Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target14-3-3 protein gamma(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383920(CHEMBL2031675)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of recombinant GST-tagged 14-3-3gamma interaction with PRAS40 in Cos7 cell lysate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target14-3-3 protein gamma(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50383921(CHEMBL2031676)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant GST-tagged 14-3-3gamma interaction with PRAS40 in Cos7 cell lysate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50607985(CHEMBL4763181)
Affinity DataIC50:  1.00E+4nMAssay Description:Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27506(3-AB | 3-aminobenzamide | CHEMBL81977)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50106188(3-Methoxy-benzamide | CHEMBL123978 | cid_98487)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  62nMAssay Description:Binding affinity to human PDGFRAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  62nMAssay Description:Binding affinity to human RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd:  10nMAssay Description:Binding affinity to human ABL2More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human FLT4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607980(CHEMBL4751648)
Affinity DataEC50:  4.40E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607981(CHEMBL4782984)
Affinity DataEC50:  1.80E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607982(CHEMBL4789502)
Affinity DataEC50:  2.10E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607983(CHEMBL1170915)
Affinity DataEC50:  1.60E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607984(CHEMBL4758598)
Affinity DataEC50:  1.10E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607985(CHEMBL4763181)
Affinity DataEC50:  1.70E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50071058((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...)
Affinity DataEC50:  1.40E+3nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607986(CHEMBL5291361)
Affinity DataEC50:  1.93E+4nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607987(CHEMBL5267681)
Affinity DataEC50:  2.09E+4nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607988(CHEMBL5291346)
Affinity DataEC50:  1.64E+4nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607989(CHEMBL5289163)
Affinity DataEC50:  2.12E+4nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50607990(CHEMBL5287369)
Affinity DataEC50:  2.21E+4nMAssay Description:Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader methodMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
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