TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of His6-tagged PHGDH (unknown origin) expressed in Escherichia coli BL21 assessed as effect on NADH fluorescence incubated for 60 mins usi...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human PTK2 (411-689 residues) expressed in Hi-5 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human PTK2 (411-689 residues) expressed in Hi-5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human PTK2 (411-689 residues) expressed in Hi-5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human PTK2 (411-689 residues) expressed in Hi-5 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human PTK2 (411-689 residues) expressed in Hi-5 cellsMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human PTK2 (411-689 residues) expressed in Hi-5 cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of PHGDH in human MDA-MB-468 cells assessed as reduction in [13C]-serine incubated for 1 hr using [13C]glucose as substrate by LC-MS/MS an...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human N-terminal GST-tagged BRD7 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScreen ...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Austria
Curated by ChEMBL
Boehringer Ingelheim Austria
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human N-terminal GST-tagged BRD9 isoform 1 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by Al...More data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Boehringer Ingelheim Rcv
Curated by ChEMBL
Boehringer Ingelheim Rcv
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged human PHGDH (4 to 315 residues) assessed as effect on NADH fluorescence incubated for 2 hrs using 3-PG substrate...More data for this Ligand-Target Pair