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Found 318 with Last Name = 'zou' and Initial = 'w'
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50154561(CHEMBL3774603)
Affinity DataKi:  42nMAssay Description:Competitive inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50552232(CHEMBL4776624)
Affinity DataKi:  68nMAssay Description:Mixed inhibition of hCES2A in human liver microsome assessed as reduction in fluorescein diacetate hydrolysis preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50571105(CHEMBL4851375)
Affinity DataKi:  90nMAssay Description:Non-competitive inhibition of CES2 in human liver microsomes using fluorescein diacetate as substrate by Lineweaver-Burk plot based Michelis-Menten e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50017698(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human CES2A using 4-methylumbelliferone as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406869(CHEMBL4165894)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406874(CHEMBL4172718)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406870(CHEMBL4168254)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  5nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  7nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406871(CHEMBL4162882)
Affinity DataIC50:  17nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50154561(CHEMBL3774603)
Affinity DataIC50:  20nMAssay Description:Inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406874(CHEMBL4172718)
Affinity DataIC50:  21nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406870(CHEMBL4168254)
Affinity DataIC50:  26nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  27nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406872(CHEMBL4165267)
Affinity DataIC50:  29nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406873(CHEMBL4162530)
Affinity DataIC50:  33nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406869(CHEMBL4165894)
Affinity DataIC50:  34nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406867(CHEMBL4161396)
Affinity DataIC50:  45nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241780(CHEMBL4105269)
Affinity DataIC50:  46nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50552232(CHEMBL4776624)
Affinity DataIC50:  52nMAssay Description:Inhibition of hCES2A in human liver microsome assessed as reduction in fluorescein diacetate hydrolysis preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241754(CHEMBL4077894)
Affinity DataIC50:  56nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-3-PPP as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406875(CHEMBL4176787)
Affinity DataIC50:  72nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241778(CHEMBL4086672)
Affinity DataIC50:  74nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241756(CHEMBL4075879)
Affinity DataIC50:  75nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241795(CHEMBL4104309)
Affinity DataIC50:  76nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241792(CHEMBL4102148)
Affinity DataIC50:  80nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241791(CHEMBL4082544)
Affinity DataIC50:  92nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase(Toxoplasma gondii)
Tulane University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Toxoplasma gondii recombinant MAPK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406875(CHEMBL4176787)
Affinity DataIC50:  107nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406867(CHEMBL4161396)
Affinity DataIC50:  115nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241782(CHEMBL4081207)
Affinity DataIC50:  120nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241781(CHEMBL4066833)
Affinity DataIC50:  120nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241789(CHEMBL4084478)
Affinity DataIC50:  130nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241755(CHEMBL4081755)
Affinity DataIC50:  130nMAssay Description:Binding affinity against sigma receptor from guinea pig brain, using [3H](+)-pentazocine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50571105(CHEMBL4851375)
Affinity DataIC50:  130nMAssay Description:Inhibition of CES2 in human liver microsomes assessed as reduction in substrate hydrolysis using fluorescein diacetate as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Dalian Institute Of Chemical Physics

Curated by ChEMBL
LigandPNGBDBM50130915(CHEBI:3122 | CHEMBL1231178)
Affinity DataIC50:  140nMAssay Description:Inhibition of CE1 in human liver microsomes using 2-(2-Benzoyl-3-methoxyphenyl) benzothiazole as substrate preincubated for 10 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241772(CHEMBL4105458)
Affinity DataIC50:  150nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241757(CHEMBL4066786)
Affinity DataIC50:  150nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241769(CHEMBL4090012)
Affinity DataIC50:  160nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406873(CHEMBL4162530)
Affinity DataIC50:  162nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406871(CHEMBL4162882)
Affinity DataIC50:  186nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jiangxi Science & Technology Normal University

Curated by ChEMBL
LigandPNGBDBM50406872(CHEMBL4165267)
Affinity DataIC50:  192nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241779(CHEMBL4082159)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241760(CHEMBL4067937)
Affinity DataIC50:  200nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase(Toxoplasma gondii)
Tulane University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295553(4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Toxoplasma gondii recombinant MAPK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241798(CHEMBL4084509)
Affinity DataIC50:  240nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241759(CHEMBL4094412)
Affinity DataIC50:  240nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241770(CHEMBL4061966)
Affinity DataIC50:  240nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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