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Target
Mitogen-activated protein kinase
Ligand
BDBM50295553
Substrate
n/a
Meas. Tech.
ChEMBL_580262 (CHEMBL1058805)
IC50
200±n/a nM
Citation
 Wei, S; Daniel, BJ; Brumlik, MJ; Burow, ME; Zou, W; Khan, IA; Wadsworth, S; Siekierka, J; Curiel, TJ Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection. Antimicrob Agents Chemother 51:4324-8 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase
Synonyms:
Mitogen-activated protein kinase 1
Type:
PROTEIN
Mol. Mass.:
58376.75
Organism:
Toxoplasma gondii
Description:
ChEMBL_580262
Residue:
532
Sequence:
MSQSTSAGGSQAVAQNPGAKLGFSMRSASIASDSVPCESGLCEAPPGVLSGAGTVFCESTYKVKIDNETVWQVPTRLKFVKKVGSGAYGCVASFEDTSASASEQGTEDDPSRREQSGETRTSQTGSAEGDSGTNKKVAVKKIGDLFRDLIDAKRIYREIKILKELKHENIINLVEILDPLTPDFEDIYLVSDLMDTDLHRVIYSRQPLTPEHHQYFLYQLLLGLSFLHQADIIHRDLKPSNILVNLNCDIKICDFGLARGLNMNPAPPPNLLPPATHRAGPAAAQDVVCTYTPPDNLSGAGKWGDQKLAAAAGAGSIAATRLVRLAHQQGSSLIGAQHQVPAKTDDASDDMELTDYVVTRWYRPPEILISPFCYSKPVDLWSVGCIFAELLGRRALFAGKDHFDQLRRIVRVLGRPSTAEINKVANEGRGRHFNNPSKGTSNTKRKRSEAARRFIESLPNSDPYKLEDLFPDASKAALDLLSNLLTFDPAKRITVQEALRHEYFEGLHSVEDEPTVTTPVNWSFDNFVPTKR
  
Inhibitor
Name:
BDBM50295553
Synonyms:
4-(4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)but-3-yn-1-ol | 4-[4-(4-Fluoro-phenyl)-1-(3-phenyl-propyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-but-3-yn-1-ol | CHEMBL190333 | RWJ-67657 | US11273153, Compound RWJ67657
Type:
Small organic molecule
Emp. Form.:
C27H24FN3O
Mol. Mass.:
425.4974
SMILES:
OCCC#Cc1nc(c(-c2ccncc2)n1CCCc1ccccc1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: