Affinity DataIC50: 0.420nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human HDAC3 complexed with NCOR2 using fluorogenic tetrapeptide RHKKAc as susbtrateMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human HDAC4 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC11 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human HDAC5 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human HDAC10 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human HDAC7 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of human HDAC7 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human HDAC9 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of RET in mouse NIH3T3MEN2A cellsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant RET active protein (unknown origin) by immunoblottingMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMT: 2°CAssay Description:PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant RET active protein (unknown origin) by immunoblottingMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant HDAC2 using Fluor de Lys Green as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC2 in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of HDAC2 in human HeLa cells using KI-104 as substrate after 40 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant RET active protein (unknown origin) by immunoblottingMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMT: 2°CAssay Description:PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human HDAC2 after 40 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of RET in mouse NIH3T3MEN2A cellsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of RET in mouse NIH3T3MEN2A cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of HDAC2 in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate incubated ...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human HDAC8 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Università
Curated by ChEMBL
Università
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant RET active protein (unknown origin) by immunoblottingMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Ronzoni Institute For Chemical And Biochem. Research
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of human HDAC1 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assayMore data for this Ligand-Target Pair