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Found 13 of ic50 for monomerid = 413455
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  0.398nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  6.31E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreenŽ Eu Kinase Binding assay run by ThermoFisher Scientific as part of ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50:  6.31E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: <1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z′-LYTEŽ assays run by ThermoFisher Scientific...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM413455((R)-7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTEŽ assays run by ThermoFisher Scientific a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent