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Found 9 Enz. Inhib. hit(s) with Target = 'Activin receptor type-1' and Ligand = 'BDBM50262079'
TargetActivin receptor type-1(Mus musculus)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  0.670nMMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM ATP by radiometric kinase assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  17nMAssay Description:Inhibition of ALK2 (unknown origin) using Ulight topo IIa (Thr 1342) peptide as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human ALK2 using dephosphorylated casein as substrate measured after 45 mins in presence of [gamma33P]ATP by scintillation counting met...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  40.7nMAssay Description:Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  41nMAssay Description:Inhibition of ALK2 (unknown origin)More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Korea University

Curated by ChEMBL
LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataIC50:  43.3nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Mus musculus)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)
Affinity DataEC50:  14nMAssay Description:Inhibition of BMP6-induced ALK2 transcriptional activity in mouse C2C12 cells expressing BRE-Luc after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair