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Found 4 Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein' and Ligand = 'BDBM136787'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM136787(US10231967, Example 30c | US8865911, 30b | US99189...)
Affinity DataIC50:  1.40nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM136787(US10231967, Example 30c | US8865911, 30b | US99189...)
Affinity DataIC50:  2.20nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM136787(US10231967, Example 30c | US8865911, 30b | US99189...)
Affinity DataIC50:  5.30nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM136787(US10231967, Example 30c | US8865911, 30b | US99189...)
Affinity DataIC50:  284nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In DepthDetails US Patent