Found 60 Enz. Inhib. hit(s) with Target = 'Androgen receptor' and Ligand = 'BDBM50425732' 
Affinity DataKi: 17nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Antagonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 86nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.35E+3nM IC50: 2.03E+3nMAssay Description:A series of dilutions of the compounds were prepared with 10% DMSO in HDAC assay buffer, and 5uL of the dilution was added to a 50uL reaction so that...More data for this Ligand-Target Pair
Affinity DataKi: 2.75E+3nMAssay Description:Reagents and instruments: radiolabeled dihydrotestosterone (DHT-d3) and unlabelled dihydrotestosterone (DHT) purchased from Sigma-Aldrich (St. Louis,...More data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataKi: 3.64E+3nMAssay Description:Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataKi: 3.64E+3nMAssay Description:Inhibition of [3H] MIB binding to rat prostate androgen receptor LBD by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.64E+3nMAssay Description:Displacement of [3H]-mibolerone from GST-tagged human AR-LBD expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.64E+3nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Affinity DataKi: 3.64E+3nMAssay Description:Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...More data for this Ligand-Target Pair
Affinity DataKi: 3.64E+3nMAssay Description:Displacement of [3H]-mibolerone from recombinant wild-type GST-tagged androgen receptor LBD (unknown origin) after 16 hrs by scintillation counting a...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of AR transcriptional activity in human LNCaP cells harboring ARR2PB-eGFP incubated for 72 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [18F]-FDHT from androgen receptor in human LNCAP/AR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Antagonist activity at androgen receptor (unknown origin) in human LNCap-ARR2PB-eGFP cells by measuring fluorescence intensity measured after 3 days ...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Antagonist activity at androgen receptor in human LNCaP cells transfected with ARR2 PB-eGFP assessed as inhibition of DHT-induced transcriptional act...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Displacement of [3H]methyltrienolone from wild-type androgen receptor in human LNCaP cells incubated for 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of full length AR transcriptional activity in human LNCAP cells harboring AR2PB-eGFP construct assessed as reduction in R1881-induced secr...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Antagonist activity against human androgen receptor expressed in human LNCap cells trasfected with ARR2PB-eGFP cells incubated for 3 days by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Antagonist activity at androgen receptor in human LNCaP cells harboring eGFP/ARRIPB incubated for 3 days by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Binding affinity to GST-tagged AR ligand binding domain (unknown origin) measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of R1881-induced full length AR transcriptional activity in human LNCAP cells harboring AR2PB-eGFP construct after 72 hrs by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist activity at androgen receptor T877A mutant (unknown origin) expressed in HEK293 cells incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Antagonist activity at wild type androgen receptor in castration-resistant human LNCaP cells assessed as inhibition of R1881-stimulated receptor tran...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK-293 cells harboring GRE-LUC and CMV-renilla luciferase assessed as inhibition of tran...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Affinity DataIC50: 218nMAssay Description:Reagents and instruments: radiolabeled dihydrotestosterone (DHT-d3) and unlabelled dihydrotestosterone (DHT) purchased from Sigma-Aldrich (St. Louis,...More data for this Ligand-Target Pair
Affinity DataIC50: 219nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 294nMAssay Description:Displacement of fluormone-DHT green from His/GST-tagged rat AR ligand binding domain after 4 to 8 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 361nMAssay Description:Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...More data for this Ligand-Target Pair
Affinity DataIC50: 361nMAssay Description:Antagonist activity at GAL4 DBD-fused androgen receptor LBD (unknown origin) transfected in UAS-bla GripTite 293 cells assessed as inhibition of R188...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of AR transcriptional activity in human LNCaP cells harboring ARR2PB-eGFP assessed as decrease in PSA levelMore data for this Ligand-Target Pair
Affinity DataIC50: 492nMAssay Description:Antagonist activity at DHT-induced Androgen receptor transcriptional activity in human HEK293 cells measured after 24 hrs by Steady-Glo reagent based...More data for this Ligand-Target Pair
Affinity DataIC50: 647nMAssay Description:Antagonist activity at androgen receptor (unknown origin) expressed in HEK293 cells using DHT as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity at androgen receptor (unknown origin) expressed in African green monkey COS7 cells assessed as inhibition of R1881-induced protei...More data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 1.32E+3nMAssay Description:Displacement of fluormone-AL Green from His-tagged/GST-fused recombinant rat androgen receptor LBD expressed in insect cells measured after 4 hrs by ...More data for this Ligand-Target Pair
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 1.32E+3nMAssay Description:Displacement of fluormone-AL Green from His-tagged/GST-fused recombinant rat androgen receptor LBD expressed in insect cells measured after 4 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.94E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Affinity DataIC50: 3.03E+3nMAssay Description:Antagonist activity at Androgen receptor (unknown origin) expressed in COS7 cells by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 3.97E+3nMAssay Description:Displacement of fluormone-AL green from GST-tagged androgen receptor LBD (unknown origin) measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.34E+3nMAssay Description:Competitive displacement of [3H]R1881 from human AR-LBD expressed in LNCaP cells incubated for 24 hrs by scintillation counting method based radiolig...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+3nMAssay Description:Displacement of Fluormone AL Green from androgen receptor ligand binding domain (unknown origin) after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.61E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of BF3 site of androgen receptor in enzalutamide-resistant human LNCAP cells assessed as reduction in PSA level after 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 915nMAssay Description:Displacement of [3H]R1881 from AR in human LNCaP cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
