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Found 5 Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2' and Ligand = 'BDBM50337620'
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50337620(((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahyd...)
Affinity DataIC50:  8.5nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50337620(((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahyd...)
Affinity DataIC50:  8.90nMAssay Description:Antagonist activity at human CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50337620(((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahyd...)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]MCP1 from human CCR2 after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50337620(((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahyd...)
Affinity DataIC50:  17nMAssay Description:Displacement of MCP-Alexa 488 from CCR2 in human whole blood after 5 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50337620(((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahyd...)
Affinity DataIC50:  18.2nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed