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Found 3 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 1' and Ligand = 'BDBM50092821'
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50092821((R)-4-Ethyl-4-methyl-1,4a,12,13a-tetrahydro-4H-2-o...)
Affinity DataIC50:  4.00E+3nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50092821((R)-4-Ethyl-4-methyl-1,4a,12,13a-tetrahydro-4H-2-o...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50092821((R)-4-Ethyl-4-methyl-1,4a,12,13a-tetrahydro-4H-2-o...)
Affinity DataEC50:  320nMAssay Description:Effective concentration against DNA topoisomerase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed