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Found 9 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50298800'
TargetDihydrofolate reductase(Candida Glabrata)
University of Connecticut

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  0.610nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes)
University of Connecticut

US Patent
LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  350nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

US Patent
LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  410nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  1.40E+3nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  1.40E+3nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed