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Found 3 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM31202'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataKi:  1.70nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataKi:  3nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM31202(JMC493432 Compound 8 | MI-63)
Affinity DataIC50:  28.3nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed