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Found 4 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM50598678'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50:  32nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of N-terminal GST tagged recombinant wild type human EGFR expressed in baculovirus infected Sf9 insect cells expression system using 5-FAM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of wild type EGFR in human A-431 cells preincubated for 4 to 5 hrs followed by EGF stimulation for 10 mins by AlphaLISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed